Recovery of left ventricular function following in vivo reexpression of cardiac myosin binding protein C.

Animals Cardiac Myosins / metabolism Cardiomyopathy, Hypertrophic / metabolism Carrier Proteins / metabolism Diastole / drug effects Doxycycline / pharmacology Mice Mice, Knockout Mice, Transgenic Myocardial Contraction / drug effects Myocardium / metabolism Phenotype Sarcomeres / drug effects Systole / drug effects Ventricular Function, Left / drug effects

Journal

The Journal of general physiology
ISSN: 1540-7748
Titre abrégé: J Gen Physiol
Pays: United States
ID NLM: 2985110R

Informations de publication

Date de publication:
07 01 2019
Historique:
received: 31 08 2018
accepted: 27 11 2018
pubmed: 24 12 2018
medline: 20 3 2020
entrez: 22 12 2018
Statut: ppublish

Résumé

The loss of cardiac myosin binding protein C (cMyBP-C) results in left ventricular dilation, cardiac hypertrophy, and impaired ventricular function in both constitutive and conditional cMyBP-C knockout (

Identifiants

DOI: 10.1085/jgp.201812238 PMID: 30573635 PMC: PMC6314388
pubmed: 30573635
pii: jgp.201812238
doi: 10.1085/jgp.201812238
pmc: PMC6314388
doi:

Substances chimiques

Carrier Proteins 0
myosin-binding protein C 0
Cardiac Myosins EC 3.6.1.-
Doxycycline N12000U13O

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

77-89

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL139883
Pays : United States
Organisme : NHLBI NIH HHS
ID : R37 HL082900
Pays : United States

Informations de copyright

© 2018 Giles et al.

Références

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Auteurs

Jasmine Giles (J)

Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.

Jitandrakumar R Patel (JR)

Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
University of Wisconsin Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.

Adam Miller (A)

Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.

Elizabeth Iverson (E)

Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.

Daniel Fitzsimons (D)

Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
University of Wisconsin Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.

Richard L Moss (RL)

Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI rlmoss@wisc.edu.
University of Wisconsin Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
ORCID: 0000-0002-8515-7132

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Recovery of left ventricular function...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Myosines › Myosine de type II › Myosines cardiaques › Recovery of left ventricular function...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Valvulopathies › Maladie de la valve aortique › Cardiomyopathie hypertrophique › Recovery of left ventricular function...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Recovery of left ventricular function...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Contraction myocardique › Diastole › Recovery of left ventricular function...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtacènes › Tétracyclines › Doxycycline › Recovery of left ventricular function...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Recovery of left ventricular function...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Recovery of left ventricular function...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Recovery of left ventricular function...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Contraction myocardique › Recovery of left ventricular function...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Recovery of left ventricular function...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Recovery of left ventricular function...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Myofibrilles › Sarcomères › Recovery of left ventricular function...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Contraction myocardique › Systole › Recovery of left ventricular function...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction ventriculaire › Fonction ventriculaire gauche › Recovery of left ventricular function...