6-Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC-1α Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1.

AMP-Activated Protein Kinases / metabolism Adiponectin / blood Aging / drug effects Animals Catechols / pharmacology Fatty Alcohols / pharmacology Insulin Resistance Lipid Metabolism / drug effects Male Mitochondria, Muscle / drug effects Muscle, Skeletal / cytology Oleic Acid / pharmacology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Rats, Sprague-Dawley Receptors, Adiponectin / metabolism Signal Transduction / drug effects
adiponectin/adipoR1, AMPK/PGC-1α, 6-gingerol insulin resistance, mitochondria

Journal

Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818

Informations de publication

Date de publication:
03 2019
Historique:
received: 03 07 2018
revised: 06 12 2018
pubmed: 24 12 2018
medline: 21 8 2019
entrez: 22 12 2018
Statut: ppublish

Résumé

This study investigates the dual actions of 6-gingerol in stimulating both plasma adiponectin and muscular adiponectin receptor signaling in naturally ageing rats. Twenty-two-month-old male SD rats were treated with 6-gingerol (0.2 mg kg 6-Gingerol may improve ectopic lipid accumulation, mitochondrial dysfunction, and insulin resistance in skeletal muscle of ageing rats. These effects rely, at least in part, on the elevated plasma adiponectin concentration and muscle AdipoR1 level to dually activate the AMPK/PGC-1α signaling pathway.

Identifiants

DOI: 10.1002/mnfr.201800649 PMID: 30575271
pubmed: 30575271
doi: 10.1002/mnfr.201800649
doi:

Substances chimiques

Adiponectin 0
Catechols 0
Fatty Alcohols 0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha 0
Ppargc1a protein, rat 0
Receptors, Adiponectin 0
adiponectin receptor 1, rat 0
adiponectin receptor 2, rat 0
Oleic Acid 2UMI9U37CP
gingerol 925QK2Z900
AMP-Activated Protein Kinases EC 2.7.11.31

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

e1800649

Informations de copyright

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Li Liu (L)

Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.

Ling Yao (L)

Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.

Shang Wang (S)

Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.

Zhiwei Chen (Z)

Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.

Tingli Han (T)

Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Peng Ma (P)

Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.

Lirong Jiang (L)

Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.

Chunlin Yuan (C)

Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.

Jinxiu Li (J)

Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.

Dazhi Ke (D)

The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Chunli Li (C)

Institute of Life Sciences, Chongqing Medical University, Chongqing, China.

Johji Yamahara (J)

Pharmafood Institute, Kyoto, Japan.

Yuhao Li (Y)

Endocrinology and Metabolism Group, Sydney Institute of Health Sciences/Sydney Institute of Traditional Chinese Medicine, Sydney, Australia.

Jianwei Wang (J)

Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-Activated Protein Kinases › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › Adiponectine › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Eucaryotes › Animaux › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Lipides › Alcools gras › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondries du muscle › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Acides oléiques › Acide oléique › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Coactivateurs de récepteurs nucléaires › Coactivateur 1-alpha du récepteur gamma activé par les proliférateurs de peroxysomes › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux adipokines › Récepteurs à l'adiponectine › 6-Gingerol Improves Ectopic Lipid...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › 6-Gingerol Improves Ectopic Lipid...