Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity.
Adult
Bariatric Surgery
Cysteine
Electron Transport Complex II
/ metabolism
Female
Humans
Hypoglycemic Agents
/ pharmacology
Insulin
/ pharmacology
Insulin Resistance
Intra-Abdominal Fat
/ drug effects
Male
Middle Aged
Obesity
/ metabolism
Organophosphorus Compounds
/ pharmacology
Oxidation-Reduction
Piperidines
/ pharmacology
Protein Processing, Post-Translational
Subcutaneous Fat
/ drug effects
adipose tissue
insulin resistance
mitochondrial complex II
mitochondrial function
obesity
succinate dehydrogenase
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
pubmed:
24
12
2018
medline:
22
11
2019
entrez:
22
12
2018
Statut:
ppublish
Résumé
Obesity, particularly visceral adiposity, has been linked to mitochondrial dysfunction and increased oxidative stress, which have been suggested as mechanisms of insulin resistance. The mechanism(s) behind this remains incompletely understood. In this study, we hypothesized that mitochondrial complex II dysfunction plays a role in impaired insulin sensitivity in visceral adipose tissue of subjects with obesity. We obtained subcutaneous and visceral adipose tissue biopsies from 43 subjects with obesity (body mass index ≥ 30 kg/m
Identifiants
pubmed: 30576243
doi: 10.1152/ajpendo.00227.2018
pmc: PMC6397365
doi:
Substances chimiques
Hypoglycemic Agents
0
Insulin
0
MitoTEMPO
0
Organophosphorus Compounds
0
Piperidines
0
Electron Transport Complex II
EC 1.3.5.1
Cysteine
K848JZ4886
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
E168-E177Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL064750
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK114897
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL135394
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126141
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114675
Pays : United States
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