IL-7 Is the Limiting Homeostatic Factor that Constrains Homeostatic Proliferation of CD8

Animals CD8-Positive T-Lymphocytes / metabolism Graft vs Host Disease / metabolism Hematopoietic Stem Cell Transplantation / methods Humans Interleukin-7 / metabolism Mice Transplantation Conditioning / methods Transplantation, Homologous / methods
GVHD Immune reconstitution Interleukin-7 Lymphocytes Lymphopenia

Journal

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Titre abrégé: Biol Blood Marrow Transplant
Pays: United States
ID NLM: 9600628

Informations de publication

Date de publication:
04 2019
Historique:
received: 05 10 2018
accepted: 11 12 2018
pubmed: 24 12 2018
medline: 8 2 2020
entrez: 22 12 2018
Statut: ppublish

Résumé

Immune reconstitution after allogeneic hematopoietic stem cell transplantation relies primarily on homeostatic proliferation (HP) of mature T lymphocytes, but this process is typically impaired during graft-versus-host disease (GVHD). We previously showed that low IL-7 levels combined with lack of dendritic cell (DC) regeneration constrain CD4

Identifiants

DOI: 10.1016/j.bbmt.2018.12.066 PMID: 30576835
pubmed: 30576835
pii: S1083-8791(18)30888-7
doi: 10.1016/j.bbmt.2018.12.066
pii:
doi:

Substances chimiques

Interleukin-7 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

648-655

Informations de copyright

Copyright © 2018 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Auteurs

Simon-David Gauthier (SD)

Départment de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada.

Moutuaata M Moutuou (MM)

Départment de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada.

Francis Daudelin (F)

Départment de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada.

Dominique Leboeuf (D)

Division d'Hématologie-Oncologie, Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada; Skolkovo Institute of Science and Technology, Moscow, Russia.

Martin Guimond (M)

Départment de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada; Division d'Hématologie-Oncologie, Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada. Electronic address: martin.guimond@umontreal.ca.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › IL-7 Is the Limiting Homeostatic Factor that...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › IL-7 Is the Limiting Homeostatic Factor that...
questionsmedicales.fr › Maladies du système immunitaire › Maladie du greffon contre l'hôte › IL-7 Is the Limiting Homeostatic Factor that...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › IL-7 Is the Limiting Homeostatic Factor that...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › IL-7 Is the Limiting Homeostatic Factor that...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-7 › IL-7 Is the Limiting Homeostatic Factor that...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › IL-7 Is the Limiting Homeostatic Factor that...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Conditionnement pour greffe › IL-7 Is the Limiting Homeostatic Factor that...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation homologue › IL-7 Is the Limiting Homeostatic Factor that...