NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis.

Adaptor Proteins, Signal Transducing Animals Apolipoproteins E / deficiency Atherosclerosis / genetics Biomarkers Enzyme Activation Gene Deletion Genetic Loci Kruppel-Like Factor 4 Mice Mice, Knockout Mice, Transgenic Muscle, Smooth, Vascular / cytology Myocytes, Smooth Muscle / cytology NADPH Oxidases / metabolism Organ Specificity / genetics Oxidation-Reduction Phenotype Proteins / genetics Reactive Oxygen Species / metabolism Receptors, LDL / deficiency Signal Transduction Tumor Necrosis Factor-alpha / metabolism
Atherosclerosis KLF4 Macrophage-like cells NOXA1 Oxidative stress Smooth muscle cells

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
02 2019
Historique:
received: 19 10 2018
revised: 16 11 2018
accepted: 29 11 2018
pubmed: 24 12 2018
medline: 4 4 2019
entrez: 22 12 2018
Statut: ppublish

Résumé

Increased reactive oxygen species (ROS) production and inflammation are key factors in the pathogenesis of atherosclerosis. We previously reported that NOX activator 1 (NOXA1) is the critical functional homolog of p67phox for NADPH oxidase activation in mouse vascular smooth muscle cells (VSMC). Here we investigated the effects of systemic and SMC-specific deletion of Noxa1 on VSMC phenotype during atherogenesis in mice. Neointimal hyperplasia following endovascular injury was lower in Noxa1-deficient mice versus the wild-type following endovascular injury. Noxa1 deletion in Apoe

Identifiants

DOI: 10.1016/j.redox.2018.11.021 PMID: 30576919 PMC: PMC6302039
pubmed: 30576919
pii: S2213-2317(18)30976-5
doi: 10.1016/j.redox.2018.11.021
pmc: PMC6302039
pii:
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Apolipoproteins E 0
Biomarkers 0
Klf4 protein, mouse 0
Kruppel-Like Factor 4 0
Noxa1 protein, mouse 0
Proteins 0
Reactive Oxygen Species 0
Receptors, LDL 0
Tumor Necrosis Factor-alpha 0
NADPH Oxidases EC 1.6.3.-

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

101063

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL111664
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139842
Pays : United States
Organisme : NIDDK NIH HHS
ID : U2C DK110768
Pays : United States

Informations de copyright

Copyright © 2018. Published by Elsevier B.V.

Références

Circ Res. 2007 Mar 2;100(4):460-73
pubmed: 17332437
J Mol Cell Cardiol. 2017 Jan;102:10-21
pubmed: 27986445
Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):480-7
pubmed: 19150879
J Biol Chem. 2010 Aug 20;285(34):26545-57
pubmed: 20558727
Atherosclerosis. 2011 Jun;216(2):321-6
pubmed: 21411092
J Clin Invest. 2011 Oct;121(10):4138-49
pubmed: 21968112
J Am Heart Assoc. 2017 Oct 27;6(11):
pubmed: 29079564
Circ Res. 2016 Dec 9;119(12):1313-1323
pubmed: 27682618
Biochem J. 2007 Aug 15;406(1):105-14
pubmed: 17501721
Circ Res. 2006 May 26;98(10):1254-63
pubmed: 16601225
Circ Res. 2009 Mar 13;104(5):609-18
pubmed: 19168440
Clin Sci (Lond). 2016 Feb;130(3):151-65
pubmed: 26678171
Cardiovasc Res. 2012 Jul 15;95(2):241-50
pubmed: 22492673
J Clin Invest. 2012 Dec;122(12):4727-31
pubmed: 23160196
FEBS J. 2010 Jul;277(13):2830-7
pubmed: 20528914
Antioxid Redox Signal. 2014 Jun 10;20(17):2794-814
pubmed: 24180474
Antioxid Redox Signal. 2015 Dec 20;23(18):1389-409
pubmed: 26054376
J Clin Invest. 2009 Sep;119(9):2634-47
pubmed: 19690389
J Clin Invest. 2001 Nov;108(10):1513-22
pubmed: 11714743
Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):345-51
pubmed: 21071705
J Biol Chem. 2016 Sep 16;291(38):20030-41
pubmed: 27489105
Am J Physiol Cell Physiol. 2007 Apr;292(4):C1493-501
pubmed: 17135302
Circ Res. 2012 May 11;110(10):1364-90
pubmed: 22581922
Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2045-51
pubmed: 22895665
Circulation. 2010 Feb 2;121(4):549-59
pubmed: 20083677
J Vasc Res. 2012;49(3):242-8
pubmed: 22433789
Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):610-621
pubmed: 29348119
Arterioscler Thromb Vasc Biol. 2008 May;28(5):812-9
pubmed: 18276911
Circ Res. 2016 Feb 19;118(4):692-702
pubmed: 26892967
Arch Med Sci. 2013 Apr 20;9(2):254-60
pubmed: 23671435
J Pathol. 2005 Oct;207(2):164-76
pubmed: 16086438
Circulation. 2005 Oct 25;112(17):2668-76
pubmed: 16230485
Circulation. 2014 Apr 15;129(15):1551-9
pubmed: 24481950
Circulation. 2003 May 20;107(19):2480-6
pubmed: 12719275
Circ Res. 2012 Aug 31;111(6):685-96
pubmed: 22811558
FEBS Lett. 2006 Jan 23;580(2):497-504
pubmed: 16386251
Circ Res. 2007 Oct 12;101(8):792-801
pubmed: 17704209
Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2836-8
pubmed: 23065827
Eur Heart J. 2002 Mar;23(5):376-83
pubmed: 11846495
J Biol Chem. 2007 Nov 23;282(47):33994-4002
pubmed: 17908689
Circulation. 2001 Jan 23;103(3):448-54
pubmed: 11157699
Free Radic Biol Med. 2013 Aug;61:473-501
pubmed: 23583330
Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2714-21
pubmed: 17823367
Free Radic Biol Med. 2006 Jul 15;41(2):193-201
pubmed: 16814099
Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2579-81
pubmed: 17110606
Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):155-9
pubmed: 17991874
J Biol Chem. 2007 Jul 6;282(27):19302-12
pubmed: 17500068
Circulation. 2013 May 7;127(18):1888-902
pubmed: 23564668
Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1706-21
pubmed: 17541027
Vascul Pharmacol. 2011 Mar-Jun;54(3-6):100-6
pubmed: 21457788
Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):385-91
pubmed: 10669634
J Biol Chem. 2007 Oct 26;282(43):31460-8
pubmed: 17726017
Genesis. 2010 Sep;48(9):568-75
pubmed: 20645308
Nat Commun. 2015 Dec 21;6:8995
pubmed: 26688060
J Cereb Blood Flow Metab. 2013 Oct;33(10):1564-73
pubmed: 23860374
Nature. 2009 Aug 6;460(7256):705-10
pubmed: 19578358
J Neurosci. 2008 Nov 12;28(46):12039-51
pubmed: 19005069
J Biol Chem. 2005 Mar 11;280(10):9719-27
pubmed: 15623517
Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):127-34
pubmed: 18032781
Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):21-7
pubmed: 11788456
J Biol Chem. 2008 May 30;283(22):15319-27
pubmed: 18378684
Mol Genet Metab. 2009 Apr;96(4):239-44
pubmed: 19157944
Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):535-46
pubmed: 25573853
Circulation. 2012 Sep 11;126(11 Suppl 1):S81-90
pubmed: 22965997
Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2696-702
pubmed: 17008593
J Clin Invest. 2010 Jan;120(1):303-14
pubmed: 20038813
Nat Med. 2015 Jun;21(6):628-37
pubmed: 25985364

Auteurs

Aleksandr E Vendrov (AE)

Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Arihiro Sumida (A)

Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Chandrika Canugovi (C)

Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Andrey Lozhkin (A)

Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Takayuki Hayami (T)

Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Nageswara R Madamanchi (NR)

Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Marschall S Runge (MS)

Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mrunge@med.umich.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

Within-subject variation of C-reactive protein and high-sensitivity C-reactive protein: A systematic review and meta-analysis.

Alex Gough, Alice Sitch, Erica Ferris et al.
1.00
C-Reactive Protein Humans Biomarkers Inflammation

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Eucaryotes › Animaux › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Métabolisme › Activation enzymatique › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › Facteur-4 de type Kruppel › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › NOXA1-dependent NADPH oxidase regulates redox...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › NOXA1-dependent NADPH oxidase regulates redox...