Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients.
Bile acid
Brain
Cholestenoic acid
Cholesterol
Mass spectrometry, Cytochrome P450
Neurodegenerative disease
Oxysterol
Sterol
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
09
09
2018
revised:
20
11
2018
accepted:
17
12
2018
pubmed:
24
12
2018
medline:
27
3
2020
entrez:
23
12
2018
Statut:
ppublish
Résumé
Using liquid chromatography - mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.
Identifiants
pubmed: 30578919
pii: S0891-5849(18)31566-1
doi: 10.1016/j.freeradbiomed.2018.12.020
pmc: PMC6597949
pii:
doi:
Substances chimiques
Bile Acids and Salts
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-52Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/I001735/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/I001735/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L001942/1
Pays : United Kingdom
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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