ASICs Mediate Food Responses in an Enteric Serotonergic Neuron that Controls Foraging Behaviors.
Acid Sensing Ion Channels
/ metabolism
Animals
Caenorhabditis elegans
/ metabolism
Caenorhabditis elegans Proteins
/ metabolism
Enteric Nervous System
/ metabolism
Feeding Behavior
/ physiology
Food
Ion Channels
/ metabolism
Locomotion
Neurons
/ metabolism
Sensory Receptor Cells
/ metabolism
Serotonergic Neurons
/ metabolism
Serotonin
Signal Transduction
ASIC
C. elegans
behavioral states
feeding
foraging
gut-brain signaling
hunger
ion channels
neural circuits
serotonin
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
10 01 2019
10 01 2019
Historique:
received:
08
02
2018
revised:
27
08
2018
accepted:
14
11
2018
pubmed:
26
12
2018
medline:
14
11
2019
entrez:
25
12
2018
Statut:
ppublish
Résumé
Animals must respond to the ingestion of food by generating adaptive behaviors, but the role of gut-brain signaling in behavioral regulation is poorly understood. Here, we identify conserved ion channels in an enteric serotonergic neuron that mediate its responses to food ingestion and decipher how these responses drive changes in foraging behavior. We show that the C. elegans serotonergic neuron NSM acts as an enteric sensory neuron that acutely detects food ingestion. We identify the novel and conserved acid-sensing ion channels (ASICs) DEL-7 and DEL-3 as NSM-enriched channels required for feeding-dependent NSM activity, which in turn drives slow locomotion while animals feed. Point mutations that alter the DEL-7 channel change NSM dynamics and associated behavioral dynamics of the organism. This study provides causal links between food ingestion, molecular and physiological properties of an enteric serotonergic neuron, and adaptive feeding behaviors, yielding a new view of how enteric neurons control behavior.
Identifiants
pubmed: 30580965
pii: S0092-8674(18)31515-0
doi: 10.1016/j.cell.2018.11.023
pmc: PMC6526957
mid: NIHMS1513056
pii:
doi:
Substances chimiques
Acid Sensing Ion Channels
0
Caenorhabditis elegans Proteins
0
Ion Channels
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-97.e14Subventions
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS076558
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104892
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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