GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology.

Alleles Basic Helix-Loop-Helix Transcription Factors / genetics Chromosomes, Human, Pair 6 / genetics Computer Simulation Diabetes Mellitus, Type 2 / complications Erectile Dysfunction / etiology Europe Genetic Predisposition to Disease Genome-Wide Association Study Humans Hypothalamus / pathology Male Repressor Proteins / genetics
GWAS Mendelian randomization SIM1 UK biobank diabetes erectile dysfunction genome-wide association impotence mendelian randomisation

Journal

American journal of human genetics
ISSN: 1537-6605
Titre abrégé: Am J Hum Genet
Pays: United States
ID NLM: 0370475

Informations de publication

Date de publication:
03 01 2019
Historique:
received: 26 07 2018
accepted: 07 11 2018
pubmed: 26 12 2018
medline: 5 11 2019
entrez: 26 12 2018
Statut: ppublish

Résumé

Erectile dysfunction (ED) is a common condition affecting more than 20% of men over 60 years, yet little is known about its genetic architecture. We performed a genome-wide association study of ED in 6,175 case subjects among 223,805 European men and identified one locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71 × 10

Identifiants

DOI: 10.1016/j.ajhg.2018.11.004 PMID: 30583798 PMC: PMC6323625
pubmed: 30583798
pii: S0002-9297(18)30407-5
doi: 10.1016/j.ajhg.2018.11.004
pmc: PMC6323625
pii:
doi:

Substances chimiques

Basic Helix-Loop-Helix Transcription Factors 0
Repressor Proteins 0
SIM1 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

157-163

Subventions

Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : P50 HD028138
Pays : United States
Organisme : British Heart Foundation
ID : FS/18/23/33512
Pays : United Kingdom

Informations de copyright

Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Références

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Auteurs

Jonas Bovijn (J)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK. Electronic address: jbovijn@well.ox.ac.uk.

Leigh Jackson (L)

Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.

Jenny Censin (J)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

Chia-Yen Chen (CY)

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

Triin Laisk (T)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu 50406, Estonia.

Samantha Laber (S)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

Teresa Ferreira (T)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK.

Sara L Pulit (SL)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.

Craig A Glastonbury (CA)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK.

Jordan W Smoller (JW)

Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

Jamie W Harrison (JW)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.

Katherine S Ruth (KS)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.

Robin N Beaumont (RN)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.

Samuel E Jones (SE)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.

Jessica Tyrrell (J)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.

Andrew R Wood (AR)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.

Michael N Weedon (MN)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.

Reedik Mägi (R)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.

Benjamin Neale (B)

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

Cecilia M Lindgren (CM)

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.

Anna Murray (A)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK. Electronic address: a.murray@exeter.ac.uk.

Michael V Holmes (MV)

National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Old Road, Oxford OX3 7LE, UK; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, Big Data Institute Building, Roosevelt Drive, University of Oxford, Oxford OX3 7LF, UK; Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de mammifère › Chromosomes humains › Chromosomes humains 6-12 et X › Chromosomes humains de la paire 6 › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Troubles mentaux › Dysfonctionnements sexuels psychogènes › Dysfonctionnement érectile › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Régions géographiques › Europe › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › GWAS Identifies Risk Locus for Erectile...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › GWAS Identifies Risk Locus for Erectile...