Mean arterial pressure during targeted temperature management and renal function after out-of-hospital cardiac arrest.
Acute Kidney Injury
Blood pressure
Cardiac arrest
Dialysis
Post-resuscitation syndrome
Journal
Journal of critical care
ISSN: 1557-8615
Titre abrégé: J Crit Care
Pays: United States
ID NLM: 8610642
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
24
10
2018
revised:
02
12
2018
accepted:
12
12
2018
pubmed:
27
12
2018
medline:
23
5
2020
entrez:
27
12
2018
Statut:
ppublish
Résumé
This study investigates the association between mean arterial pressure (MAP) and renal function after out-of-hospital cardiac arrest (OHCA). Post-hoc analysis of 851 comatose OHCA-patients surviving >48 h included in the targeted temperature management (TTM)-trial. Patients were stratified by mean MAP during TTM in the following groups; <70 mmHg (22%), 70-80 mmHg (43%), and > 80 mmHg (35%). Median (interquartile range) eGFR (ml/min/1.73 m Low mean MAP during TTM was independently associated with decreased renal function and need of renal replacement therapy in a large cohort of comatose OHCA-patients. Increasing MAP above the recommended 65 mmHg could potentially be renal-protective. This hypothesis should be investigated in prospective trials.
Identifiants
pubmed: 30586655
pii: S0883-9441(18)31505-3
doi: 10.1016/j.jcrc.2018.12.009
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
234-241Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.