Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation.

Animals Aorta / metabolism Aortitis / genetics Atherosclerosis / genetics Bone Marrow Cells / metabolism Bone Marrow Transplantation Case-Control Studies Disease Models, Animal Down-Regulation Hematopoiesis Humans Mice, Inbred C57BL Mice, Knockout, ApoE MicroRNAs / genetics Plaque, Atherosclerotic RNA, Long Noncoding / genetics Signal Transduction
RNA atherosclerosis inflammation leukocytes

Journal

Circulation
ISSN: 1524-4539
Titre abrégé: Circulation
Pays: United States
ID NLM: 0147763

Informations de publication

Date de publication:
05 03 2019
Historique:
pubmed: 28 12 2018
medline: 20 12 2019
entrez: 28 12 2018
Statut: ppublish

Résumé

The majority of the human genome comprises noncoding sequences, which are in part transcribed as long noncoding RNAs (lncRNAs). lncRNAs exhibit multiple functions, including the epigenetic control of gene expression. In this study, the effect of the lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) on atherosclerosis was examined. The effect of MALAT1 on atherosclerosis was determined in apolipoprotein E-deficient (Apoe Apoe Reduced levels of MALAT1 augment atherosclerotic lesion formation in mice and are associated with human atherosclerotic disease. The proatherosclerotic effects observed in Malat1

Sections du résumé

BACKGROUND
The majority of the human genome comprises noncoding sequences, which are in part transcribed as long noncoding RNAs (lncRNAs). lncRNAs exhibit multiple functions, including the epigenetic control of gene expression. In this study, the effect of the lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) on atherosclerosis was examined.
METHODS
The effect of MALAT1 on atherosclerosis was determined in apolipoprotein E-deficient (Apoe
RESULTS
Apoe
CONCLUSIONS
Reduced levels of MALAT1 augment atherosclerotic lesion formation in mice and are associated with human atherosclerotic disease. The proatherosclerotic effects observed in Malat1

Identifiants

DOI: 10.1161/CIRCULATIONAHA.117.029015 PMID: 30586743
pubmed: 30586743
doi: 10.1161/CIRCULATIONAHA.117.029015
doi:

Substances chimiques

MALAT1 long non-coding RNA, human 0
Malat1 long non-coding RNA, mouse 0
MicroRNAs 0
Mirn503 microRNA, mouse 0
RNA, Long Noncoding 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1320-1334

Commentaires et corrections

Type : ErratumIn

Auteurs

Sebastian Cremer (S)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).
Department of Cardiology, Internal Medicine III, Johann Wolfgang Goethe-University Hospital, Frankfurt, Germany (S.C., A.Z.).

Katharina M Michalik (KM)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).

Ariane Fischer (A)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).

Larissa Pfisterer (L)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).

Nicolas Jaé (N)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).

Carla Winter (C)

Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilians University, Munich, Germany (C. Winter, C. Weber, L.M., O.S.).

Reinier A Boon (RA)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).
Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, the Netherlands (R.A.B.).
German Centre of Cardiovascular Research (DZHK), Berlin-Wedding, Germany (R.A.B., C. Weber, O.S., A.Z., S.D.).

Marion Muhly-Reinholz (M)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).

David John (D)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).

Shizuka Uchida (S)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).
Cardiovascular Innovation Institute University of Louisville, KY (S.U.).

Christian Weber (C)

Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilians University, Munich, Germany (C. Winter, C. Weber, L.M., O.S.).
German Centre of Cardiovascular Research (DZHK), Berlin-Wedding, Germany (R.A.B., C. Weber, O.S., A.Z., S.D.).
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands (C. Weber).

Wolfgang Poller (W)

Charité Centrum für Herz-, Kreislauf- und Gefäßmedizin, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Germany (W.P.).

Stefan Günther (S)

Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (S.G., T.B.).

Thomas Braun (T)

Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (S.G., T.B.).

Daniel Y Li (DY)

Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar der Technischen Universität München, Germany (D.Y.L., L.M.).

Lars Maegdefessel (L)

Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilians University, Munich, Germany (C. Winter, C. Weber, L.M., O.S.).
Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar der Technischen Universität München, Germany (D.Y.L., L.M.).

Ljubica Perisic Matic (L)

Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden (L.P.M., U.H.).

Ulf Hedin (U)

Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden (L.P.M., U.H.).

Oliver Soehnlein (O)

Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilians University, Munich, Germany (C. Winter, C. Weber, L.M., O.S.).
German Centre of Cardiovascular Research (DZHK), Berlin-Wedding, Germany (R.A.B., C. Weber, O.S., A.Z., S.D.).
Department of Physiology and Pharmacology (FyFa), Karolinska Institutet, Stockholm, Sweden (O.S.).

Andreas Zeiher (A)

Department of Cardiology, Internal Medicine III, Johann Wolfgang Goethe-University Hospital, Frankfurt, Germany (S.C., A.Z.).
German Centre of Cardiovascular Research (DZHK), Berlin-Wedding, Germany (R.A.B., C. Weber, O.S., A.Z., S.D.).

Stefanie Dimmeler (S)

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).
German Centre of Cardiovascular Research (DZHK), Berlin-Wedding, Germany (R.A.B., C. Weber, O.S., A.Z., S.D.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Aorte › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Vascularite › Aortite › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation de tissu › Transplantation de moelle osseuse › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Souris invalidées pour les gènes ApoE › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Hematopoietic Deficiency of the Long Noncoding...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Hematopoietic Deficiency of the Long Noncoding...