Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillian-Universität (LMU) München, German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany and Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.