Iron Regulator Hepcidin Impairs Macrophage-Dependent Cardiac Repair After Injury.

Animals Animals, Newborn Atrial Remodeling / physiology Bone Marrow Cells / cytology Heart / physiology Hepcidins / genetics Interleukin-13 / metabolism Interleukin-4 / metabolism Macrophages / cytology Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells / cytology Mice Mice, Inbred C57BL Mice, Transgenic Myocardial Infarction / pathology Myocytes, Cardiac / cytology Regeneration Ventricular Remodeling / physiology
inflammation macrophage myocardial infarction regeneration

Journal

Circulation
ISSN: 1524-4539
Titre abrégé: Circulation
Pays: United States
ID NLM: 0147763

Informations de publication

Date de publication:
19 03 2019
Historique:
pubmed: 28 12 2018
medline: 31 12 2019
entrez: 28 12 2018
Statut: ppublish

Résumé

Defective systemic and local iron metabolism correlates with cardiac disorders. Hepcidin, a master iron sensor, actively tunes iron trafficking. We hypothesized that hepcidin could play a key role to locally regulate cardiac homeostasis after acute myocardial infarction. Cardiac repair was analyzed in mice harboring specific cardiomyocyte or myeloid cell deficiency of hepcidin and challenged with acute myocardial infarction. We found that the expression of hepcidin was elevated after acute myocardial infarction and the specific deletion of hepcidin in cardiomyocytes failed to improve cardiac repair and function. However, transplantation of bone marrow-derived cells from hepcidin-deficient mice ( Hamp Hepcidin refrains macrophage-induced cardiac repair and regeneration through modulation of IL-4/IL-13 pathways.

Sections du résumé

BACKGROUND
Defective systemic and local iron metabolism correlates with cardiac disorders. Hepcidin, a master iron sensor, actively tunes iron trafficking. We hypothesized that hepcidin could play a key role to locally regulate cardiac homeostasis after acute myocardial infarction.
METHODS
Cardiac repair was analyzed in mice harboring specific cardiomyocyte or myeloid cell deficiency of hepcidin and challenged with acute myocardial infarction.
RESULTS
We found that the expression of hepcidin was elevated after acute myocardial infarction and the specific deletion of hepcidin in cardiomyocytes failed to improve cardiac repair and function. However, transplantation of bone marrow-derived cells from hepcidin-deficient mice ( Hamp
CONCLUSIONS
Hepcidin refrains macrophage-induced cardiac repair and regeneration through modulation of IL-4/IL-13 pathways.

Identifiants

DOI: 10.1161/CIRCULATIONAHA.118.034545 PMID: 30586758
pubmed: 30586758
doi: 10.1161/CIRCULATIONAHA.118.034545
doi:

Substances chimiques

Hepcidins 0
Interleukin-13 0
Interleukin-4 207137-56-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1530-1547

Auteurs

Ivana Zlatanova (I)

Institut National de la Santé et de la Recherche Médicale, UMRS-970, Paris Centre de Recherche Cardiovasculaire, Université Paris Descartes, Sorbonne Paris Cité, France (I.Z., C.P., W.B., J.V., M.L., J.-S-.S.).

Cristina Pinto (C)

Institut National de la Santé et de la Recherche Médicale, UMRS-970, Paris Centre de Recherche Cardiovasculaire, Université Paris Descartes, Sorbonne Paris Cité, France (I.Z., C.P., W.B., J.V., M.L., J.-S-.S.).

Philippe Bonnin (P)

Institut National de la Santé et de la Recherche Médicale, Unit 965, Départment de physiologie Clinique, Assistance Publique Hôpitaux de Paris, Hôpital Lariboisière, France (P.B.).

Jacques R R Mathieu (JRR)

Institut National de la Santé et de la Recherche Médicale U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, France (J.R.R.M., S.V., C.P.).

Wineke Bakker (W)

Institut National de la Santé et de la Recherche Médicale, UMRS-970, Paris Centre de Recherche Cardiovasculaire, Université Paris Descartes, Sorbonne Paris Cité, France (I.Z., C.P., W.B., J.V., M.L., J.-S-.S.).

Jose Vilar (J)

Institut National de la Santé et de la Recherche Médicale, UMRS-970, Paris Centre de Recherche Cardiovasculaire, Université Paris Descartes, Sorbonne Paris Cité, France (I.Z., C.P., W.B., J.V., M.L., J.-S-.S.).

Mathilde Lemitre (M)

Institut National de la Santé et de la Recherche Médicale, UMRS-970, Paris Centre de Recherche Cardiovasculaire, Université Paris Descartes, Sorbonne Paris Cité, France (I.Z., C.P., W.B., J.V., M.L., J.-S-.S.).

David Voehringer (D)

University Hospital Erlangen, Wasserturmstrasse 3/5, Germany (D.V.).

Sophie Vaulont (S)

Institut National de la Santé et de la Recherche Médicale U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, France (J.R.R.M., S.V., C.P.).

Carole Peyssonnaux (C)

Institut National de la Santé et de la Recherche Médicale U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, France (J.R.R.M., S.V., C.P.).

Jean-Sébastien Silvestre (JS)

Institut National de la Santé et de la Recherche Médicale, UMRS-970, Paris Centre de Recherche Cardiovasculaire, Université Paris Descartes, Sorbonne Paris Cité, France (I.Z., C.P., W.B., J.V., M.L., J.-S-.S.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction auriculaire › Remodelage auriculaire › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Hepcidines › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-13 › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-4 › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches mésenchymateuses › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Iron Regulator Hepcidin Impairs...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction ventriculaire › Remodelage ventriculaire › Iron Regulator Hepcidin Impairs...