Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1.
chronic cutaneous itch
dorsal root ganglion neurons
inflammatory mediators
transient receptor potential channel ankyrin transmembrane protein 1
transient receptor potential channel vanilloid 1
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
13
08
2018
accepted:
19
11
2018
pubmed:
28
12
2018
medline:
18
6
2019
entrez:
28
12
2018
Statut:
ppublish
Résumé
Chronic itch with an itch-scratch vicious circle is a significant problem in a large amount of diseases. Some of these diseases, such as psoriasis, atopic dermatitis, prurigo nodularis, Sézary syndrome, uremic pruritus, diabetes and jaundice, are common. For a very long time, chronic itch has been a thorny problem with few effective treatments. Because of this, itch researchers and dermatologists seek to find the mechanisms among chronic itch, inflammatory cytokines and neurons. As an immediate area of research focus, we are going to find the peripheral cross-talk between neurons and skin cells. Two receptors, named transient receptor potential channel vanilloid 1 and transient receptor potential channel ankyrin transmembrane protein 1, have been shown to play important roles in chronic itch. Many advances have been made so far this decade. This review talks about the updated mechanism of itch-related inflammatory cytokines via transient receptor potential channels in cutaneous chronic itch and corresponding diseases. The search for itch-related inflammatory mediators and the structure of transient receptor potential channels this decade could deepen our understanding of the mechanism of itch and help us find more treatments of chronic itch in the future.
Identifiants
pubmed: 30588658
doi: 10.1111/1346-8138.14749
pmc: PMC6590237
doi:
Substances chimiques
Cytokines
0
TRPA1 Cation Channel
0
TRPV Cation Channels
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
177-185Subventions
Organisme : Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences
ID : CAMS-2017-12M-1-011
Informations de copyright
© 2018 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.
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