Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study.
co-medications
cross-sectional
heart transplantation
immunosuppressants
international
medication adherence
Journal
Clinical therapeutics
ISSN: 1879-114X
Titre abrégé: Clin Ther
Pays: United States
ID NLM: 7706726
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
23
05
2018
revised:
07
11
2018
accepted:
12
11
2018
pubmed:
29
12
2018
medline:
31
12
2019
entrez:
29
12
2018
Statut:
ppublish
Résumé
To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. MNA was significantly (α = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). The observed MNA necessitates adherence-enhancing interventions encompassing the entire post-heart transplant medication regimen. ClinicalTrials.gov identifier: NCT01608477.
Identifiants
pubmed: 30591285
pii: S0149-2918(18)30561-7
doi: 10.1016/j.clinthera.2018.11.007
pii:
doi:
Substances chimiques
Immunosuppressive Agents
0
Banques de données
ClinicalTrials.gov
['NCT01608477']
Types de publication
Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
130-136Investigateurs
Marisa G Crespo-Leiro
(MG)
Sandra Cupples
(S)
Paolo De Simone
(P)
Albert Groenewoud
(A)
Christiane Kugler
(C)
Linda Ohler
(L)
Johan Van Cleemput
(J)
Alain Jean Poncelet
(AJ)
Laurent Sebbag
(L)
Magali Michel
(M)
Andrée Bernard
(A)
Andreas Doesch
(A)
Ugolino Livi
(U)
Luciano Potena
(L)
Vicens Brossa-Loidi
(V)
Javier Segovia-Cubero
(J)
Luis Almenar-Bonet
(L)
Carmen Segura Saint-Gerons
(CS)
Paul Mohacsi
(P)
Eva Horvath
(E)
Cheryl Riotto
(C)
Gareth Parry
(G)
Ashi Firouzi
(A)
Stella Kozuszko
(S)
Haissam Haddad
(H)
Annemarie Kaan
(A)
Grant Fisher
(G)
Tara Miller
(T)
Maureen Flattery
(M)
Kristin Ludrosky
(K)
Nancy Albert
(N)
Bernice Coleman
(B)
Jacqueline Trammell
(J)
Flavio Epstein
(F)
Katherine St Clair
(K)
Andrew Kao
(A)
Maria Molina
(M)
Karyn Ryan Canales
(KR)
Samira Scalso de Almeida
(S)
Andrea Cotait Ayoub
(AC)
Fernanda Barone
(F)
Michelle Harkess
(M)
Joanne Maddicks-Law
(J)
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.