Facile preparation of a controlled-release tubular scaffold for blood vessel implantation.
Alkenes
/ chemistry
Animals
Blood Vessel Prosthesis Implantation
Carotid Arteries
/ chemistry
Cell Adhesion
Cell Proliferation
Cells, Cultured
Female
Gelatin
/ chemistry
Human Umbilical Vein Endothelial Cells
/ chemistry
Humans
Nanoparticles
/ chemistry
Particle Size
Polyphenols
/ chemistry
Polyurethanes
/ chemistry
Porosity
Rabbits
Silicon Dioxide
/ chemistry
Surface Properties
Tissue Engineering
Tissue Scaffolds
Anticoagulation
Controlled release
Mechanical properties
Tubular scaffolds
Vascular tissue engineering
Journal
Journal of colloid and interface science
ISSN: 1095-7103
Titre abrégé: J Colloid Interface Sci
Pays: United States
ID NLM: 0043125
Informations de publication
Date de publication:
15 Mar 2019
15 Mar 2019
Historique:
received:
20
10
2018
revised:
16
12
2018
accepted:
22
12
2018
pubmed:
30
12
2018
medline:
4
4
2019
entrez:
30
12
2018
Statut:
ppublish
Résumé
Salvianic acid-loaded mesoporous silica nanoparticles into gelatin/polyurethane bilayered small-diameter tubular scaffold were prepared by thermally induced phase separation (TIPS) and electrospinning. Mesoporous silica nanoparticles (MSNs) were selected as carriers to load salvianic acid (SAL). The SAL-loaded MSNs (SAL@MSNs) with an optimized SAL loading efficiency of 10% was initially dispersed in gelatin solution and under a vacuum freeze-drying process as an inner layer of vascular scaffolds. Then, poly(ester-urethane)urea (C-PEEUU) nanofibers were electrospun outside the SAL@MSNs/Gelatin vascular scaffold to strengthen the spongy matrix. The loaded SAL within the MSNs/Gelatin/C-PEEUU bilayered small-diameter tubular scaffold showed a sustained release profile and good mechanical properties. In addition, the drug-loaded composite scaffold showed no unfavorable effects on the adhesion and proliferation of endothelial cells. Moreover, no intimal hyperplasia and acute thrombosis was observed in the short-term implantation in rabbit's carotid artery. We believe the SAL@MSNs/Gelatin/C-PEEUU bilayered vascular scaffolds have promise for vascular tissue engineering applications.
Identifiants
pubmed: 30594010
pii: S0021-9797(18)31527-3
doi: 10.1016/j.jcis.2018.12.086
pii:
doi:
Substances chimiques
Alkenes
0
Polyphenols
0
Polyurethanes
0
salvianolic acid
0
Silicon Dioxide
7631-86-9
Gelatin
9000-70-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-360Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.