How Far Are we Away From an Improved Vaccine For Tuberculosis? Current Efforts and Future Prospects.
Adjuvants, Immunologic
Antibodies, Bacterial
/ biosynthesis
Antigens, Bacterial
/ immunology
BCG Vaccine
/ administration & dosage
Clinical Trials as Topic
Forecasting
Genetic Vectors
Humans
Immunization, Secondary
Immunogenicity, Vaccine
Infant
Infant, Newborn
Mycobacterium tuberculosis
/ immunology
Tuberculosis
/ prevention & control
Tuberculosis Vaccines
/ classification
Vaccines, Subunit
Vaccines, Synthetic
Vaccinia virus
/ genetics
Bacille Calmette-Guérin
Bacilo Calmette-Guérin
Clinical trials
Ensayos clínicos
Tuberculosis
Vaccine
Vacuna
Journal
Archivos de bronconeumologia
ISSN: 2173-5751
Titre abrégé: Arch Bronconeumol (Engl Ed)
Pays: Spain
ID NLM: 101777538
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
27
07
2018
revised:
12
11
2018
accepted:
12
11
2018
pubmed:
31
12
2018
medline:
6
10
2020
entrez:
31
12
2018
Statut:
ppublish
Résumé
Tuberculosis still is a major public health problem worldwide, and vaccines may play a major role in its eradication. However, despite 20 years of intensive research, we still do not have a better vaccine than the Bacille Calmette-Guérin vaccine, which has been used since 1921 but exhibits only limited efficacy in the field. This effort has not, however, been entirely in vain as our understanding of TB vaccinology has been substantially expanded and there are currently 17 vaccine candidates in clinical development and several more in preclinical trials. This manuscript reviews the most important recent advances, concerns raised and future prospects in the TB vaccinology field.
Identifiants
pubmed: 30594319
pii: S0300-2896(18)30446-0
doi: 10.1016/j.arbres.2018.11.002
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antibodies, Bacterial
0
Antigens, Bacterial
0
BCG Vaccine
0
Tuberculosis Vaccines
0
Vaccines, Subunit
0
Vaccines, Synthetic
0
Types de publication
Journal Article
Review
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
373-377Informations de copyright
Copyright © 2018 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.