Platelet Glycoprotein VI Haplotypes and the Presentation of Paediatric Sepsis.
Adolescent
Age of Onset
Blood Platelets
/ metabolism
Case-Control Studies
Cell-Derived Microparticles
/ genetics
Child
Child, Preschool
Disease Progression
Female
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Humans
Infant
Infant, Newborn
Male
Phenotype
Platelet Membrane Glycoproteins
/ genetics
Risk Factors
Sepsis
/ blood
Severity of Illness Index
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
pubmed:
1
1
2019
medline:
10
7
2019
entrez:
1
1
2019
Statut:
ppublish
Résumé
Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on the platelet membrane receptor, glycoprotein VI (GPVI), and its role in platelet microparticle (pMP) release. The GPVI receptor is a platelet-specific collagen membrane receptor that, upon ligand binding, facilitates the release of pMPs. As membrane-bound platelet fragments of less than 1 μm, pMPs are known to have both pro-inflammatory and pro-coagulant properties. Thus, pMPs are potentially impacting sepsis at multiple stages of the inflammatory response. Studies are presented documenting the impact of the most common GPVI haplotypes, GPVIa and GPVIb, on pMP levels and release in healthy individuals (
Identifiants
pubmed: 30597490
doi: 10.1055/s-0038-1676794
doi:
Substances chimiques
Platelet Membrane Glycoproteins
0
platelet membrane glycoprotein VI
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
431-438Informations de copyright
Georg Thieme Verlag KG Stuttgart · New York.
Déclaration de conflit d'intérêts
None declared.