A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD).
Adult
Agriculture
Air Pollutants, Occupational
/ analysis
Denmark
/ epidemiology
Dust
/ analysis
Female
Follow-Up Studies
Humans
Logistic Models
Male
Manufacturing Industry
Middle Aged
Occupational Exposure
/ analysis
Pulmonary Disease, Chronic Obstructive
/ epidemiology
Risk Factors
Smoking
/ epidemiology
Wood
Young Adult
chronic obstructive pulmonary disease (copd)
epidemiology
occupational exposure
organic dusts
Journal
Occupational and environmental medicine
ISSN: 1470-7926
Titre abrégé: Occup Environ Med
Pays: England
ID NLM: 9422759
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
26
06
2018
revised:
17
10
2018
accepted:
07
11
2018
pubmed:
2
1
2019
medline:
13
11
2019
entrez:
2
1
2019
Statut:
ppublish
Résumé
To study exposure-response relations between cumulative organic dust exposure and incident chronic obstructive pulmonary disease (COPD) among subjects employed in the Danish farming and wood industry. We studied exposure-response relations between cumulative organic dust exposure and incident COPD (1997-2013) among individuals born during 1950-1977 in Denmark ever employed in the farming or wood industry (n=1 75 409). Industry-specific employment history (1964-2007), combined with time-dependent farming and wood industry-specific exposure matrices defined cumulative exposure. We used logistic regression analysis with discrete survival function adjusting for age, sex and calendar year. Adjustment for smoking status was explored in a subgroup of 4023 with smoking information available. Cumulative organic dust exposure was inversely associated with COPD (adjusted rate ratios (RR Our findings show no increased risk of COPD with increasing occupational exposure to organic dust in the farming or wood industry. Potential residual confounding by smoking can, however, not be ruled out.
Identifiants
pubmed: 30598459
pii: oemed-2018-105323
doi: 10.1136/oemed-2018-105323
pmc: PMC6581073
doi:
Substances chimiques
Air Pollutants, Occupational
0
Dust
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105-113Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Natl Cancer Inst. 2012 Jun 6;104(11):869-83
pubmed: 22393207
Lancet. 2012 Dec 15;380(9859):2095-128
pubmed: 23245604
Occup Environ Med. 2010 Jan;67(1):67-71
pubmed: 20029026
Scand J Public Health. 2011 Jul;39(7 Suppl):12-6
pubmed: 21898916
J Asthma. 2012 Feb;49(1):2-4
pubmed: 21895566
Soc Sci Med. 2003 Jan;56(1):1-15
pubmed: 12435547
Occup Environ Med. 2017 Jul;74(7):531-542
pubmed: 28404791
Ann Occup Hyg. 2006 Aug;50(6):549-61
pubmed: 16571638
Scand J Public Health. 2011 Jul;39(7 Suppl):22-5
pubmed: 21775345
J Expo Sci Environ Epidemiol. 2015 Mar-Apr;25(2):123-37
pubmed: 24280684
Environ Res. 2017 Feb;153:126-134
pubmed: 27940105
Ann Occup Hyg. 2008 Jun;52(4):227-38
pubmed: 18407937
Int J Chron Obstruct Pulmon Dis. 2017 Feb 22;12:725-734
pubmed: 28260879
Epidemiology. 2017 Mar;28(2):300-310
pubmed: 27984421
Epidemiology. 2015 Mar;26(2):204-12
pubmed: 25536456
Respir Med. 2011 Dec;105(12):1872-84
pubmed: 21852081
Eur Respir J. 2008 Feb;31(2):334-42
pubmed: 17989115
Scand J Work Environ Health. 2014 Jan;40(1):19-35
pubmed: 24220056
Occup Environ Med. 2015 Oct;72(10):707-13
pubmed: 26265668
Thorax. 2005 Aug;60(8):645-51
pubmed: 16061705
Ann Occup Hyg. 1999 Feb;43(2):107-15
pubmed: 10206039
Am J Epidemiol. 1999 Feb 15;149(4):347-52
pubmed: 10025477
Epidemiology. 2011 Jul;22(4):599-606
pubmed: 21543985
Ann Occup Hyg. 2008 Jul;52(5):303-16
pubmed: 18515847
Epidemiology. 1994 Mar;5(2):189-96
pubmed: 8172994
Occup Med (Lond). 2015 Jun;65(4):270-82
pubmed: 25972608
J Occup Environ Med. 2002 Jan;44(1):82-98
pubmed: 11802471
Thorax. 2017 Nov;72(11):990-997
pubmed: 28687678
Ann Occup Hyg. 2001 Mar;45(2):157-64
pubmed: 11182430
Am J Respir Crit Care Med. 2005 Nov 1;172(9):1139-45
pubmed: 16040784
Thorax. 2017 Mar;72(3):236-244
pubmed: 27672121
Clin Epidemiol. 2010 Aug 09;2:45-50
pubmed: 20865102
Ann Occup Hyg. 2007 Mar;51(2):161-72
pubmed: 17046960
J Agromedicine. 2004;9(2):223-38
pubmed: 19785218
J Environ Monit. 2012 Feb;14(2):604-14
pubmed: 22159073
J Occup Environ Med. 1998 Jan;40(1):63-8
pubmed: 9467122