Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo.
Alzheimer’s disease
Aβ
Neurofibrillary tangles
Paired helical filaments
Prion-like tau propagation
Tau seeding
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
29
11
2018
accepted:
17
12
2018
revised:
17
12
2018
pubmed:
2
1
2019
medline:
21
4
2020
entrez:
2
1
2019
Statut:
ppublish
Résumé
Neuropathological analysis in Alzheimer's disease (AD) and experimental evidence in transgenic models overexpressing frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) mutant tau suggest that amyloid-β pathology enhances the development of tau pathology. In this work, we analyzed this interaction independently of the overexpression of an FTDP-17 mutant tau, by analyzing tau pathology in wild-type (WT), 5xFAD, APP
Identifiants
pubmed: 30599077
doi: 10.1007/s00401-018-1953-5
pii: 10.1007/s00401-018-1953-5
doi:
Substances chimiques
Amyloid beta-Peptides
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
397-412Subventions
Organisme : Belgian Fonds de la Recherche Scientifique Médicale
ID : T.0023.15
Pays : International