Comparative validity and responsiveness of PHQ-ADS and other composite anxiety-depression measures.
Anxiety Disorders
/ diagnosis
Area Under Curve
Depressive Disorder
/ diagnosis
Female
Humans
Male
Mental Health
Middle Aged
Musculoskeletal Pain
/ diagnosis
Patient Health Questionnaire
/ standards
Psychiatric Status Rating Scales
/ standards
Psychometrics
/ instrumentation
Quality of Life
Reproducibility of Results
Sickness Impact Profile
Veterans
Anxiety
Depression
Measures
Psychometrics
Responsiveness
Validity
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
13
09
2018
revised:
20
11
2018
accepted:
24
12
2018
pubmed:
2
1
2019
medline:
2
4
2019
entrez:
2
1
2019
Statut:
ppublish
Résumé
Composite measures that assess the overall burden of anxiety and depressive symptoms have been infrequently evaluated in the same study. The objective of this study was to compare the validity and responsiveness of the Patient Health Questionnaire Anxiety-Depression Scale (PHQ-ADS) and other composite anxiety-depression measures. The sample comprised 256 primary care patients enrolled in a telecare trial of chronic musculoskeletal pain and comorbid depression and/or anxiety. Measures included the PHQ-ADS; the 8-item and 4-item depression and anxiety scales from the PROMIS profiles; the PHQ-anxiety-depression scale (PHQ-4); the SF-36 Mental Health scale; and the SF-12 Mental Component Summary scale. Correlations among these measures and health-related quality of life measures were examined. Responsiveness was evaluated by standardized response means, area under the curve (AUC) analyses, and treatment effect sizes in the trial. Convergent and construct validity was supported by strong correlations of the composite depression-anxiety measures with one another and moderate correlations with health-related quality of life measures, respectively. All composite measures differentiated patients who were better at 3 months, whereas the PHQ-ADS and PHQ-4 also distinguished the subgroup that had worsened. AUCs for composite measures were generally similar, whereas treatment effect sizes were largest for the PHQ-ADS. The study sample was predominantly male veterans enrolled from primary care who had chronic musculoskeletal pain and moderate levels of depression and anxiety. Composite depression and anxiety scales are valid and responsive measures that may be useful as outcomes in research and clinical practice.
Sections du résumé
BACKGROUND
Composite measures that assess the overall burden of anxiety and depressive symptoms have been infrequently evaluated in the same study. The objective of this study was to compare the validity and responsiveness of the Patient Health Questionnaire Anxiety-Depression Scale (PHQ-ADS) and other composite anxiety-depression measures.
METHODS
The sample comprised 256 primary care patients enrolled in a telecare trial of chronic musculoskeletal pain and comorbid depression and/or anxiety. Measures included the PHQ-ADS; the 8-item and 4-item depression and anxiety scales from the PROMIS profiles; the PHQ-anxiety-depression scale (PHQ-4); the SF-36 Mental Health scale; and the SF-12 Mental Component Summary scale. Correlations among these measures and health-related quality of life measures were examined. Responsiveness was evaluated by standardized response means, area under the curve (AUC) analyses, and treatment effect sizes in the trial.
RESULTS
Convergent and construct validity was supported by strong correlations of the composite depression-anxiety measures with one another and moderate correlations with health-related quality of life measures, respectively. All composite measures differentiated patients who were better at 3 months, whereas the PHQ-ADS and PHQ-4 also distinguished the subgroup that had worsened. AUCs for composite measures were generally similar, whereas treatment effect sizes were largest for the PHQ-ADS.
LIMITATIONS
The study sample was predominantly male veterans enrolled from primary care who had chronic musculoskeletal pain and moderate levels of depression and anxiety.
CONCLUSIONS
Composite depression and anxiety scales are valid and responsive measures that may be useful as outcomes in research and clinical practice.
Identifiants
pubmed: 30599366
pii: S0165-0327(18)32041-X
doi: 10.1016/j.jad.2018.12.098
pii:
doi:
Types de publication
Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
437-443Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.