CD147 as an apoptosis regulator in spermatogenesis: deciphering its association with matrix metalloproteinases' pathway.
Adult
Apoptosis
/ physiology
Basigin
/ metabolism
Cell Movement
Humans
Infertility, Male
/ genetics
Male
Matrix Metalloproteinase 2
/ physiology
Matrix Metalloproteinase 7
/ physiology
Matrix Metalloproteinase 9
/ physiology
Matrix Metalloproteinases
/ physiology
ROC Curve
Spermatogenesis
/ physiology
Transcriptome
Apoptosis
CD147
Infertility
MMPs
Spermatogenesis
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
05
09
2018
accepted:
10
12
2018
pubmed:
3
1
2019
medline:
6
7
2019
entrez:
3
1
2019
Statut:
ppublish
Résumé
CD147 plays an important role in germ cells migration and survival/apoptosis during the spermatogenesis process. However, to best of our knowledge, there is no report on the exact role of CD147 gene in the regulation of germ cells apoptosis through matrix metalloproteinases (MMPs). So, the current study aims to evaluate the role of CD147 gene expression in the regulation of germ cells apoptosis in conjunction with MMPs. Real-Time PCR was applied to investigate the expression of CD147, MMP2, MMP7, and MMP9 genes in the azoospermic patients and fertile males. Receiver-operating characteristic curve was used to interpret gene expression data. According to our results, a significant decrease in the expression of CD147 gene and an increase in MMPs genes expression were observed in infertile patients compared to fertile males. These results proved this fact that the CD147 gene has an important role in the regulation of germ cells apoptosis via a MMPs-dependent pathway.
Identifiants
pubmed: 30600459
doi: 10.1007/s11033-018-4568-y
pii: 10.1007/s11033-018-4568-y
doi:
Substances chimiques
BSG protein, human
0
Basigin
136894-56-9
Matrix Metalloproteinases
EC 3.4.24.-
MMP7 protein, human
EC 3.4.24.23
Matrix Metalloproteinase 7
EC 3.4.24.23
MMP2 protein, human
EC 3.4.24.24
Matrix Metalloproteinase 2
EC 3.4.24.24
MMP9 protein, human
EC 3.4.24.35
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1099-1105Subventions
Organisme : Kermanshah University of Medical Sciences
ID : 96689
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