Synthesis, crystal structure, and biological evaluation of optically active 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-3-carbonitriles: Antiepileptic, antidiabetic, and anticholinergics potentials.
antidiabetic potential
asymmetric synthesis
carbonic anhydrase
metabolic enzymes
optically active 4H-chromenes
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
02
11
2018
revised:
16
11
2018
accepted:
27
11
2018
pubmed:
3
1
2019
medline:
6
5
2019
entrez:
3
1
2019
Statut:
ppublish
Résumé
In the presence of chiral organic catalysts, the optically active 4H-chromine was synthesized from the multicomponent condensation of 5,5-dimethylcyclohexane-1,3-dione with malononitrile and methylene-active compound, and the specific angle of rotation of the compounds was determined in the AUTOPOL-III polarimeter and their structures were confirmed by the X-ray spectroscopic analysis method. These optically active 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-3-carbonitriles were effective inhibitors of α-glycosidase, the cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with K
Identifiants
pubmed: 30600532
doi: 10.1002/ardp.201800317
doi:
Substances chimiques
Anticonvulsants
0
Cholinergic Antagonists
0
Hypoglycemic Agents
0
Nitriles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1800317Informations de copyright
© 2019 Deutsche Pharmazeutische Gesellschaft.