Mechanism and Regulation of Centriole and Cilium Biogenesis.
cell cycle
centriole
centrosome
cilia
ciliopathy
mitosis
Journal
Annual review of biochemistry
ISSN: 1545-4509
Titre abrégé: Annu Rev Biochem
Pays: United States
ID NLM: 2985150R
Informations de publication
Date de publication:
20 06 2019
20 06 2019
Historique:
pubmed:
3
1
2019
medline:
1
7
2020
entrez:
3
1
2019
Statut:
ppublish
Résumé
The centriole is an ancient microtubule-based organelle with a conserved nine-fold symmetry. Centrioles form the core of centrosomes, which organize the interphase microtubule cytoskeleton of most animal cells and form the poles of the mitotic spindle. Centrioles can also be modified to form basal bodies, which template the formation of cilia and play central roles in cellular signaling, fluid movement, and locomotion. In this review, we discuss developments in our understanding of the biogenesis of centrioles and cilia and the regulatory controls that govern their structure and number. We also discuss how defects in these processes contribute to a spectrum of human diseases and how new technologies have expanded our understanding of centriole and cilium biology, revealing exciting avenues for future exploration.
Identifiants
pubmed: 30601682
doi: 10.1146/annurev-biochem-013118-111153
pmc: PMC6588485
mid: NIHMS1033825
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
691-724Subventions
Organisme : NICHD NIH HHS
ID : R00 HD082280
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114119
Pays : United States
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