Putting out the blaze: The neural mechanisms underlying sexual inhibition.
Adult
Brain Mapping
/ methods
Executive Function
/ physiology
Female
Frontal Lobe
/ diagnostic imaging
Healthy Volunteers
Humans
Inhibition, Psychological
Magnetic Resonance Imaging
/ methods
Male
Motivation
/ physiology
Prefrontal Cortex
/ diagnostic imaging
Sexual Behavior
/ psychology
Young Adult
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
26
03
2018
accepted:
25
11
2018
entrez:
3
1
2019
pubmed:
3
1
2019
medline:
24
9
2019
Statut:
epublish
Résumé
The successful inhibition of sexual thoughts, desires, and behaviors represents an essential ability for adequate functioning in our daily life. Evidence derived from lesion studies indicates a link between sexual inhibition and the general ability for behavioral and cognitive control. This is further supported by the high comorbidity of sexual compulsivity with other inhibition-related disorders. Here, we aimed at investigating whether sexual and general inhibition recruit overlapping or distinct neural correlates in the brain. Furthermore, we investigated the specificity of two different kinds of sexual inhibition: inhibition of sexually driven motor responses and inhibition of sexual incoming information. To this end, 22 healthy participants underwent functional Magnetic Resonance Imaging (fMRI) while performing a task requiring general response inhibition (Go/No-go), as well as cognitive and motivational sexual inhibition (Negative Affective Priming and Approach-Avoidance task). Our within-subject within-session design enabled the direct statistical comparison between general and sexual inhibitory mechanisms. The general inhibition task recruited mainly prefrontal and insular regions, replicating previous findings. In contrast, the two types of sexual inhibition activated both common and distinct neural networks. Whereas cognitive sexual inhibition engaged the inferior frontal gyrus, the orbitofrontal cortex and the fusiform gyrus, motivational sexual inhibition was characterized by a hypoactivation in the anterolateral prefrontal cortex. Both types of sexual inhibition recruited the inferior frontal gyrus and the inferotemporal cortex. However, the activity of the inferior frontal gyrus did not correlate with behavioral inhibitory scores. These results support the hypothesis of inhibitory processing being an emergent property of a functional network.
Identifiants
pubmed: 30601828
doi: 10.1371/journal.pone.0208809
pii: PONE-D-18-09141
pmc: PMC6314635
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0208809Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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