Design and in Vivo Characterization of A
Adenosine
/ analogs & derivatives
Adenosine A1 Receptor Agonists
/ chemical synthesis
Animals
Bridged Bicyclo Compounds
/ chemical synthesis
CHO Cells
Cricetulus
Drug Design
HEK293 Cells
Humans
Macaca fascicularis
Male
Mice, Inbred C57BL
Molecular Docking Simulation
Molecular Structure
Receptor, Adenosine A1
/ metabolism
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
14 02 2019
14 02 2019
Historique:
pubmed:
4
1
2019
medline:
4
3
2020
entrez:
4
1
2019
Statut:
ppublish
Résumé
(N)-Methanocarba ([3.1.0]bicyclohexyl) adenosines and corresponding ribosides were synthesized to identify novel A
Identifiants
pubmed: 30605331
doi: 10.1021/acs.jmedchem.8b01662
pmc: PMC6467784
mid: NIHMS1011817
doi:
Substances chimiques
Adenosine A1 Receptor Agonists
0
Bridged Bicyclo Compounds
0
Receptor, Adenosine A1
0
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1502-1522Subventions
Organisme : Intramural NIH HHS
ID : ZIA DK031117
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133589
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AG000356
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK031117-31
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK075063
Pays : United States
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