Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity.

Acetylcholinesterase / chemistry Carbonic Anhydrase I / antagonists & inhibitors Carbonic Anhydrase II / antagonists & inhibitors Carbonic Anhydrase Inhibitors / chemical synthesis Cell Line, Tumor Cell Survival / drug effects Cholinesterase Inhibitors / chemical synthesis Humans Pyrazoles / chemistry Structure-Activity Relationship Sulfonamides / chemistry Benzenesulfonamides
Acetylcholinesterase Carbonic anhydrase Cytotoxicity Pyrazoline Sulfonamide

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
03 2019
Historique:
received: 15 11 2018
revised: 11 12 2018
accepted: 19 12 2018
pubmed: 4 1 2019
medline: 14 1 2020
entrez: 4 1 2019
Statut: ppublish

Résumé

4-(3-Substitutedphenyl-5-polymethoxyphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamides (9-16) were synthesized and their chemical structures were elucidated by

Identifiants

DOI: 10.1016/j.bioorg.2018.12.028 PMID: 30605787
pubmed: 30605787
pii: S0045-2068(18)31324-5
doi: 10.1016/j.bioorg.2018.12.028
pii:
doi:

Substances chimiques

Carbonic Anhydrase Inhibitors 0
Cholinesterase Inhibitors 0
Pyrazoles 0
Sulfonamides 0
pyrazole 3QD5KJZ7ZJ
Acetylcholinesterase EC 3.1.1.7
Carbonic Anhydrase I EC 4.2.1.-
Carbonic Anhydrase II EC 4.2.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

511-517

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Dilan Ozmen Ozgun (D)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Agri Ibrahim Cecen University, Agri, Turkey.

Halise Inci Gul (HI)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey. Electronic address: incigul1967@yahoo.com.

Cem Yamali (C)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey.

Hiroshi Sakagami (H)

Division of Pharmacology, Meikai University School of Dentistry, Saitama, Sakado, Japan; Meikai University Research Institute of Odontology (M-RIO), Meikai University School of Dentistry, Saitama, Sakado, Japan.

Ilhami Gulcin (I)

Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Murat Sukuroglu (M)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey.

Claudiu T Supuran (CT)

Neurofarba Department e Laboratorio di Chimica Bioinorganica, Universita Degli Studi di Firenze, Sesto Fiorentino (Florence), Italy.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Carbonic anhydrases › Carbonic anhydrase I › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Carbonic anhydrases › Carbonic anhydrase II › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de l'anhydrase carbonique › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis and bioactivities of pyrazoline...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Synthesis and bioactivities of pyrazoline...