Urinary Levels of Trimethylamine-N-Oxide and Incident Coronary Heart Disease: A Prospective Investigation Among Urban Chinese Adults.
Chinese
cardiovascular disease risk factors
gut microbiota
metabolomics
nested case‐control study
nutrition
prospective cohort study
trimethylamine‐N‐oxide
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
08 01 2019
08 01 2019
Historique:
entrez:
5
1
2019
pubmed:
5
1
2019
medline:
4
1
2020
Statut:
ppublish
Résumé
Background Trimethylamine-N-oxide ( TMAO ), a diet-derived, gut microbial-host cometabolite, has been associated with adverse cardiovascular outcomes in patient populations; however, evidence is lacking from prospective studies conducted in general populations and non-Western populations. Methods and Results We evaluated urinary levels of TMAO and its precursor metabolites (ie, choline, betaine, and carnitine) in relation to risk of coronary heart disease ( CHD ) among Chinese adults in a nested case-control study, including 275 participants with incident CHD and 275 individually matched controls. We found that urinary TMAO , but not its precursors, was associated with risk of CHD . The odds ratio for the highest versus lowest quartiles of TMAO was 1.91 (95% CI, 1.08-3.35; P
Identifiants
pubmed: 30606084
doi: 10.1161/JAHA.118.010606
pmc: PMC6405718
doi:
Substances chimiques
Biomarkers
0
Methylamines
0
trimethyloxamine
FLD0K1SJ1A
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e010606Subventions
Organisme : NCI NIH HHS
ID : UM1 CA173640
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182910
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
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