Genetic polymorphisms with erythrocyte traits in malaria endemic areas of Mali.
ABO Blood-Group System
/ genetics
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Child
Child, Preschool
Cross-Sectional Studies
Erythrocytes
/ metabolism
Female
Gene Frequency
/ genetics
Genetic Predisposition to Disease
/ genetics
Haplotypes
/ genetics
Humans
Malaria
/ genetics
Male
Mali
/ epidemiology
Middle Aged
Phenotype
Polymorphism, Genetic
/ genetics
Young Adult
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
01
2018
accepted:
16
12
2018
entrez:
5
1
2019
pubmed:
5
1
2019
medline:
1
10
2019
Statut:
epublish
Résumé
African populations are characterized by high degree of genetic diversity. This high genetic diversity could result from the natural selection pressure. Several studies have described an association between some genetic diversities and difference of susceptibility to infectious diseases like malaria. It seems therefore important to consider genetic diversity impact when interpreting results of clinical trials in malaria endemic areas. This study aimed to determine the genetic polymorphism with erythrocyte traits in different populations of malaria endemic area in Mali. The cross-sectional surveys were carried out in different ethnic groups living in malaria endemic areas in Mali. Six milliliters of whole blood were collected in EDTA vials from each participant after informed consent has been obtained. The ABO, RH, Kell, MNSs, Kidd and Duffy systems phenotypes were assessed by the technique of gel filtration. A total of 231 subjects were included from six villages. The blood groups phenotypes O (40.7%) and A (31.2%) were more frequent with respective allele frequencies of 0.65 and 0.21. In the RH system the haplotypes R0 (0.55), r (0.20) and R1 (0.13) were the most frequent. Seven percent (7%) of Duffy positive and 4% of Glycophorin B deficiency (S-s-) were observed among participants. All participants were Kell negative. ABO and RH systems were polymorphic in these ethnic groups in Mali. Their implication in susceptibility to malaria should be taken into account in clinical trials interpretation, and for prevention of blood transfusion risks during anemia frequently caused by malaria in children.
Identifiants
pubmed: 30608964
doi: 10.1371/journal.pone.0209966
pii: PONE-D-18-02923
pmc: PMC6319707
doi:
Substances chimiques
ABO Blood-Group System
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0209966Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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