The relationship between microRNAs and Rab family GTPases in human cancers.

3' Untranslated Regions / genetics Gene Expression Regulation, Neoplastic / genetics Humans MicroRNAs / genetics Neoplasms / genetics Vesicular Transport Proteins / metabolism rab GTP-Binding Proteins / metabolism
Rabs cancer therapy miRNAs

Journal

Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222

Informations de publication

Date de publication:
08 2019
Historique:
received: 06 06 2018
accepted: 30 11 2018
pubmed: 5 1 2019
medline: 22 5 2020
entrez: 5 1 2019
Statut: ppublish

Résumé

microRNAs (miRNAs), as a group of noncoding RNAs, posttranscriptionally control gene expression by binding to 3'-untranslated region (3'-UTR). Ras-associated binding (Rab) proteins function as molecular switches for regulating vesicular transport, which mainly have oncogenic roles in cancer development and preventing the efficacy of chemotherapies. Increased evidence supported that miRNAs/Rabs interaction have been determined as potential therapeutics for cancer therapy. Nevertheless, instability and cross-targeting of miRNAs are main limitations of using miRNA-based therapeutic. The mutual interplay between Rabs and miRNAs has been poorly understood. In the present review, we focused on the essence and activity of these molecules in cancer pathogenesis. Also, numerous hindrances and potential methods in the expansion of miRNA as an anticancer therapeutics are mentioned.

Identifiants

DOI: 10.1002/jcp.28038 PMID: 30609026
pubmed: 30609026
doi: 10.1002/jcp.28038
doi:

Substances chimiques

3' Untranslated Regions 0
MicroRNAs 0
Vesicular Transport Proteins 0
rab GTP-Binding Proteins EC 3.6.5.2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

12341-12352

Informations de copyright

© 2019 Wiley Periodicals, Inc.

Auteurs

Arman Shahabi (A)

Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Behrooz Naghili (B)

Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Khalil Ansarin (K)

Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Nosratollah Zarghami (N)

Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
ORCID: 0000-0002-4236-4537

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Régions non traduites › Régions 3' non traduites › The relationship between microRNAs and Rab...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › The relationship between microRNAs and Rab...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The relationship between microRNAs and Rab...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › The relationship between microRNAs and Rab...
questionsmedicales.fr › Tumeurs › The relationship between microRNAs and Rab...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › The relationship between microRNAs and Rab...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rab › The relationship between microRNAs and Rab...