Investigation of Radiofrequency Ultrasound-Based Fibrotic Tissue Strain Imaging Method Employing Endogenous Motion.
cardiovascular
integrated spectral coefficient
motion tracking
stiffness
Journal
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
ISSN: 1550-9613
Titre abrégé: J Ultrasound Med
Pays: England
ID NLM: 8211547
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
07
12
2017
revised:
13
11
2018
accepted:
10
12
2018
pubmed:
5
1
2019
medline:
11
2
2020
entrez:
5
1
2019
Statut:
ppublish
Résumé
The paper presents the results of an initial clinical study, which were obtained using the strain elastography imaging method based on radio frequency ultrasound signal analysis. The technique employs endogenous motion of the liver induced by beating heart and vascular pulsatility as an excitation source of tissue microdisplacement. The potential for fibrotic tissue characterization was demonstrated using a clinical data set of radio frequency ultrasound signals (23 healthy controls, 21 subjects with hepatitis, and 16 subjects with liver cirrhosis). Parametric maps, which represent the tissue strain, were derived from the gradient of the integrated spectral coefficient parameter, and correlations with the stage of liver disease were evaluated. Average endogenous strain derived from the gradient of the integrated spectral coefficient parameter and variability (standard deviation) of the strain were evaluated in the rectangular regions of interest (sizes, 1 × 1 and 2 × 2 cm) defined by the observer. The assessment of strain was performed in different frequency subbands of endogenous motion (0-10 Hz and 10-20 Hz). The best distinction between the groups was observed for the average strain derived from the gradient of the integrated spectral coefficient parameter: the controls, 13.30 ± 6.62; hepatitis, 7.12 ± 7.45; cirrhosis, 3.95 ± 2.44 μm/cm (region of interest, 1 × 1 cm; frequency subband 0-10 Hz), and 10.48 ± 6.02, 8.27 ± 5.41, 3.89 ± 2.07 μm/cm, respectively (2 × 2 cm, 0-10 Hz). The investigated strain parameters showed statistically significant differences (P < .001) for the different stages of liver fibrosis in most of the cases and proved this method to be feasible.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2315-2327Subventions
Organisme : Research, Development and Innovation Fund of Kaunas University of Technology
ID : MTEPI-L-17003
Organisme : Research, Development and Innovation Fund of Kaunas University of Technology
ID : MTEPI-L-16012
Organisme : Research Fund of Lithuanian University of Health Sciences
ID : SV5-074/BN17-99
Organisme : Research Fund of Lithuanian University of Health Sciences
ID : LSMU-21
Informations de copyright
© 2019 by the American Institute of Ultrasound in Medicine.
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