Long-term effect of arsenic exposure: Results from an occupational cohort study.
arsenic
epidemiology of disasters
industrial accident
lung cancer
petrochemical plant
Journal
American journal of industrial medicine
ISSN: 1097-0274
Titre abrégé: Am J Ind Med
Pays: United States
ID NLM: 8101110
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
accepted:
10
12
2018
pubmed:
5
1
2019
medline:
15
2
2020
entrez:
5
1
2019
Statut:
ppublish
Résumé
In 1976 in Manfredonia (Italy), arsenic was released into the atmosphere due to an accident in a petrochemical plant. We aimed to analyze the mortality of workers involved in the factory for the site cleaning activities. The cohort consisted of 1467 workers grouped into contract, fertilizer, and plastic workers. The outcome of interest was mortality for specific causes. Standardized mortality ratios (SMR) and 95% confidence intervals (95%CI) were computed. For all workers and all causes of death combined, the SMR was less than 1.0. Mortality ratios were increased for malignant neoplasms of the pleura, bone and melanoma of the skin. Contract workers, the group mostly exposed to arsenic, showed statistically significant SMRs for several malignancies, in particular for lung cancer (SMR = 1.26; 95%CI: 1.05-1.54). Overall, the results reported here on mortality among persons occupationally exposed to arsenic are consistent with the literature and biologically plausible.
Sections du résumé
BACKGROUND
In 1976 in Manfredonia (Italy), arsenic was released into the atmosphere due to an accident in a petrochemical plant. We aimed to analyze the mortality of workers involved in the factory for the site cleaning activities.
METHODS
The cohort consisted of 1467 workers grouped into contract, fertilizer, and plastic workers. The outcome of interest was mortality for specific causes. Standardized mortality ratios (SMR) and 95% confidence intervals (95%CI) were computed.
RESULTS
For all workers and all causes of death combined, the SMR was less than 1.0. Mortality ratios were increased for malignant neoplasms of the pleura, bone and melanoma of the skin. Contract workers, the group mostly exposed to arsenic, showed statistically significant SMRs for several malignancies, in particular for lung cancer (SMR = 1.26; 95%CI: 1.05-1.54).
CONCLUSIONS
Overall, the results reported here on mortality among persons occupationally exposed to arsenic are consistent with the literature and biologically plausible.
Substances chimiques
Air Pollutants
0
Arsenic
N712M78A8G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
145-155Subventions
Organisme : Municipality of Manfredonia
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.