Kinetic and Angiogenic Activity of Circulating Endothelial Colony Forming Cells in Patients with Infantile Haemangioma Receiving Propranolol.

Adrenergic beta-Antagonists / therapeutic use Antigens, CD34 / metabolism Calcium / chemistry Calcium Signaling Cell Movement Chemokine CXCL12 / metabolism Endothelial Cells / cytology Endothelial Progenitor Cells / cytology Female Flow Cytometry Hemangioma / drug therapy Humans Infant Infant, Newborn Kinetics Leukocyte Common Antigens / metabolism Longitudinal Studies Male Mesenchymal Stem Cells / cytology Neovascularization, Pathologic Neovascularization, Physiologic Phenotype Propranolol / therapeutic use Receptors, CXCR4 / metabolism

Journal

Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063

Informations de publication

Date de publication:
Feb 2019
Historique:
pubmed: 5 1 2019
medline: 5 4 2019
entrez: 5 1 2019
Statut: ppublish

Résumé

Endothelial progenitor cells (EPCs) have been suggested to contribute to the neovascularization of infantile haemangioma (IH). There is strong evidence of the efficacy of propranolol in the treatment of IH, possibly by inhibiting both vasculogenesis and angiogenesis in the tumour. We evaluate the frequency of circulating endothelial colony forming cells (ECFCs), as the best EPC surrogate, in patients with IH at diagnosis and while receiving propranolol by an ex vivo 12-month longitudinal study. Biological aspects of the ECFCs, such as their in vitro angiogenic potential, membrane CXCR4 expression and Ca

Identifiants

DOI: 10.1055/s-0038-1676855 PMID: 30609443
pubmed: 30609443
doi: 10.1055/s-0038-1676855
doi:

Substances chimiques

Adrenergic beta-Antagonists 0
Antigens, CD34 0
CXCL12 protein, human 0
CXCR4 protein, human 0
Chemokine CXCL12 0
Receptors, CXCR4 0
Propranolol 9Y8NXQ24VQ
Leukocyte Common Antigens EC 3.1.3.48
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

274-284

Informations de copyright

Georg Thieme Verlag KG Stuttgart · New York.

Déclaration de conflit d'intérêts

None declared.

Auteurs

Rita Campanelli (R)

Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Alessia Claudia Codazzi (AC)

Cardiology Clinic of Pediatrics, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Valentina Poletto (V)

Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Carlotta Abbà (C)

Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Paolo Catarsi (P)

Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Gabriela Fois (G)

Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Maria Antonietta Avanzini (MA)

Immunology and Transplantation Laboratory/Cell Factory/Pediatric Haematology/Oncology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Valeria Brazzelli (V)

Department of Clinical-Surgical, Diagnostic and Pediatric Science, Institute of Dermatology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Chryssoula Tzialla (C)

Neonatal Intensive Care Unit, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Annalisa De Silvestri (A)

Epidemiology Service, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Carmine Tinelli (C)

Epidemiology Service, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Amelia Licari (A)

Department of Pediatrics, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy.

Roberto Berra-Romani (R)

Department of Biomedicine, School of Medicine, Benemérita Universidad Autónoma de Puebla, Puebla, México.

Estella Zuccolo (E)

Laboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani," University of Pavia, Pavia, Italy.

Francesco Moccia (F)

Laboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani," University of Pavia, Pavia, Italy.

Savina Mannarino (S)

Cardiology Clinic of Pediatrics, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Vittorio Rosti (V)

Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Margherita Massa (M)

Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Antagonistes adrénergiques › Antagonistes bêta-adrénergiques › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Antigènes CD34 › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL12 › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Progéniteurs endothéliaux › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu vasculaire › Hémangiome › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Receptor-Like Protein Tyrosine Phosphatases › Receptor-Like Protein Tyrosine Phosphatases, Class 1 › Antigènes CD45 › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Néovascularisation physiologique › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Propranolol › Kinetic and Angiogenic Activity of Circulating...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteurs CXCR4 › Kinetic and Angiogenic Activity of Circulating...