Protocol for systematic review and meta-analysis of sex hormones and diabetes risk in ageing men and women of African ancestry.
Female
Humans
Male
Aging
Black People
Diabetes Mellitus, Type 2
/ epidemiology
Estradiol
/ metabolism
Follicle Stimulating Hormone
/ metabolism
Gonadal Steroid Hormones
/ metabolism
Luteinizing Hormone
/ metabolism
Sex Hormone-Binding Globulin
/ metabolism
Testosterone
/ metabolism
Meta-Analysis as Topic
Systematic Reviews as Topic
epidemiology
general endocrinology
general medicine (see internal medicine)
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
03 01 2019
03 01 2019
Historique:
entrez:
6
1
2019
pubmed:
6
1
2019
medline:
11
2
2020
Statut:
epublish
Résumé
To present the protocol of a systematic review and meta-analysis of the available evidence examining the association between sex hormones and type 2 diabetes risk in ageing men and women of African descent. We shall conduct a comprehensive search of published studies that examined the association between sex hormones and type 2 diabetes risk in men and women aged ≥40 years from 01/01/1980 to 31/03/2018 with no language restriction. Databases to be searched include: PubMed, Scopus, Cochrane Library, Cumulative Index to Nursing and Allied Health, ISI Web of Science, Clinical Trial registries, Google Scholar and institutional websites such as the WHO, American Diabetes Association, International Diabetes Federation, World Diabetes Foundation, European Association for the Study of Diabetes, African Journal Online and ProQuest databases. This protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. Independent screening for eligible studies using defined criteria and data extraction, will be completed in duplicate. Discrepancies will be resolved by consensus or consultation with a third researcher. Risk of bias of included studies will be assessed by the appropriate Cochrane risk of bias tool. The overall association estimates will be pooled using appropriate meta-analytic techniques. Heterogeneity will be assessed using Cochrane Q statistic and the inconsistency index (I No ethics clearance is required as no primary data will be collected. The systematic review and meta-analysis are part of a PhD project at WITS University (Johannesburg, South Africa) and results will be presented at conferences and published in a peer-review journal. The results will guide future population specific interventions. CRD42017074581.
Identifiants
pubmed: 30610025
pii: bmjopen-2018-024446
doi: 10.1136/bmjopen-2018-024446
pmc: PMC6326342
doi:
Substances chimiques
Estradiol
4TI98Z838E
Follicle Stimulating Hormone
9002-68-0
Gonadal Steroid Hormones
0
Luteinizing Hormone
9002-67-9
Sex Hormone-Binding Globulin
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e024446Subventions
Organisme : Medical Research Council
ID : MC_PC_16099
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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