Membrane-Anchored Serine Proteases and Protease-Activated Receptor-2-Mediated Signaling: Co-Conspirators in Cancer Progression.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
07
06
2018
revised:
12
10
2018
accepted:
07
11
2018
pubmed:
6
1
2019
medline:
2
11
2019
entrez:
6
1
2019
Statut:
ppublish
Résumé
Pericellular proteolysis provides a significant advantage to developing tumors through the ability to remodel the extracellular matrix, promote cell invasion and migration, and facilitate angiogenesis. Recent advances demonstrate that pericellular proteases can also communicate directly to cells by activation of a unique group of transmembrane G-protein-coupled receptors (GPCR) known as protease-activated receptors (PAR). In this review, we discuss the specific roles of one of four mammalian PARs, namely PAR-2, which is overexpressed in advanced stage tumors and is activated by trypsin-like serine proteases that are highly expressed or otherwise dysregulated in many cancers. We highlight recent insights into the ability of different protease agonists to bias PAR-2 signaling and the newly emerging evidence for an interplay between PAR-2 and membrane-anchored serine proteases, which may co-conspire to promote tumor progression and metastasis. Interfering with these pathways might provide unique opportunities for the development of new mechanism-based strategies for the treatment of advanced and metastatic cancers.
Identifiants
pubmed: 30610085
pii: 0008-5472.CAN-18-1745
doi: 10.1158/0008-5472.CAN-18-1745
pmc: PMC6335149
mid: NIHMS1512753
doi:
Substances chimiques
Glycosylphosphatidylinositols
0
Receptor, PAR-2
0
Serine Proteases
EC 3.4.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-310Subventions
Organisme : NCI NIH HHS
ID : R01 CA196988
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118390
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA154274
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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