Neuroradiological worsening of brain abscess after adalimumab and methotrexate withdrawal: Do not forget Immune Reconstitution Inflammatory Syndrome.
Abscess
Immune Reconstitution Inflammatory Syndrome
MRI
Methotrexate
TNF-blocker
Journal
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
ISSN: 1532-2653
Titre abrégé: J Clin Neurosci
Pays: Scotland
ID NLM: 9433352
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
25
11
2018
accepted:
23
12
2018
pubmed:
7
1
2019
medline:
25
4
2019
entrez:
7
1
2019
Statut:
ppublish
Résumé
The incidence of brain abscess is higher among immunosuppressed patients. We report a case of a brain abscess in the temporal lobe in a patient under treatment with adalimumab and methotrexate, who developed radiological worsening. Clinical remission was essential to suspect Immune Reconstitution Inflammatory Syndrome and to continue empirical antimicrobial therapy due to the low suspicion of worsening of the abscess itself.
Identifiants
pubmed: 30611629
pii: S0967-5868(18)32038-1
doi: 10.1016/j.jocn.2018.12.018
pii:
doi:
Substances chimiques
Immunosuppressive Agents
0
Adalimumab
FYS6T7F842
Methotrexate
YL5FZ2Y5U1
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
240-242Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.