Sphingosine 1-phosphate-mediated activation of ezrin-radixin-moesin proteins contributes to cytoskeletal remodeling and changes of membrane properties in epithelial otic vesicle progenitors.
Actin Cytoskeleton
/ metabolism
Animals
Cell Line
Cell Membrane
/ physiology
Cochlea
/ cytology
Cytoskeletal Proteins
/ metabolism
Electrophysiological Phenomena
Epithelial Cells
/ metabolism
Extracellular Signal-Regulated MAP Kinases
/ metabolism
Lysophospholipids
/ physiology
Membrane Proteins
/ metabolism
Mice
Microfilament Proteins
/ metabolism
Protein Kinase C
/ metabolism
Proto-Oncogene Proteins c-akt
/ metabolism
Receptors, Lysosphingolipid
/ physiology
Sphingosine
/ analogs & derivatives
Sphingosine-1-Phosphate Receptors
Stem Cells
/ physiology
p38 Mitogen-Activated Protein Kinases
/ metabolism
Actin cytoskeleton
Differentiation
Ezrin-radixin-moesin (ERM)
Otic vesicle-derived epithelial progenitors
Sphingosine 1-phosphate
Voltage-gated potassium currents
Journal
Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
15
08
2018
revised:
24
11
2018
accepted:
18
12
2018
pubmed:
7
1
2019
medline:
10
9
2019
entrez:
7
1
2019
Statut:
ppublish
Résumé
Hearing loss is among the most prevalent sensory impairments in humans. Cochlear implantable devices represent the current therapies for hearing loss but have various shortcomings. ERM (ezrin- radixin -moesin) are a family of adaptor proteins that link plasma membrane with actin cytoskeleton, playing a crucial role in cell morphology and in the formation of membrane protrusions. Recently, bioactive sphingolipids have emerged as regulators of ERM proteins. Sphingosine 1-phosphate (S1P) is a pleiotropic sphingolipid which regulates fundamental cellular functions such as proliferation, survival, migration as well as processes such as development and inflammation mainly via ligation to its specific receptors S1PR (S1P
Identifiants
pubmed: 30611767
pii: S0167-4889(18)30270-2
doi: 10.1016/j.bbamcr.2018.12.007
pii:
doi:
Substances chimiques
Cytoskeletal Proteins
0
Lysophospholipids
0
Membrane Proteins
0
Microfilament Proteins
0
Receptors, Lysosphingolipid
0
Sphingosine-1-Phosphate Receptors
0
ezrin
0
sphingosine-1-phosphate receptor-2, mouse
0
moesin
144131-77-1
radixin
144517-21-5
sphingosine 1-phosphate
26993-30-6
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Protein Kinase C
EC 2.7.11.13
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
554-565Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.