A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus.
Adolescent
Adrenal Cortex Hormones
/ pharmacology
Adult
Aged
Antipsychotic Agents
/ pharmacology
Double-Blind Method
Female
Functional Laterality
Glutamic Acid
/ metabolism
Hippocampus
/ diagnostic imaging
Humans
Lamotrigine
/ pharmacology
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Memory Disorders
/ diagnostic imaging
Middle Aged
Young Adult
Corticosteroid
Hippocampus
Magnetic resonance imaging
Memory
Prednisone
Journal
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
ISSN: 1873-7862
Titre abrégé: Eur Neuropsychopharmacol
Pays: Netherlands
ID NLM: 9111390
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
31
07
2018
revised:
13
11
2018
accepted:
16
12
2018
pubmed:
8
1
2019
medline:
27
8
2019
entrez:
8
1
2019
Statut:
ppublish
Résumé
In animals, stress and corticosteroid excess are associated with decreases in memory performance and hippocampal volume that may be prevented with agents that decrease glutamate release. Humans also demonstrate changes in memory and hippocampus with corticosteroids. In this report the effects of glutamate-release inhibitor lamotrigine on hippocampal structure and memory were examined in people receiving medically needed prescription corticosteroid therapy. A total of 54 outpatient adults (n = 28 women) receiving chronic (≥ 6 months) oral corticosteroid therapy were randomized to lamotrigine or placebo for 48 weeks. Declarative memory was assessed using the Rey Auditory Verbal Learning Test (RAVLT); structural magnetic resonance imaging (MRI) as well as single-voxel proton MR spectroscopy (
Identifiants
pubmed: 30612854
pii: S0924-977X(18)32002-9
doi: 10.1016/j.euroneuro.2018.12.012
pmc: PMC9167568
mid: NIHMS1784401
pii:
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Antipsychotic Agents
0
Glutamic Acid
3KX376GY7L
Lamotrigine
U3H27498KS
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
376-383Subventions
Organisme : NIA NIH HHS
ID : R01 AG053555
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH102392
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115932
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier B.V.
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