Effect of mild hypercapnia on outcome and histological injury in a porcine post cardiac arrest model.
Animals
Arterial Pressure
Blood Gas Analysis
/ methods
Carbon Dioxide
/ blood
Cardiopulmonary Resuscitation
/ methods
Disease Models, Animal
Heart Arrest
/ physiopathology
Hemodynamics
Hypercapnia
/ blood
Neuroprotection
/ physiology
Recovery of Function
Respiration, Artificial
/ methods
Survival Analysis
Swine
Hypercapnia
Neurological outcome
Post cardiac arrest
Survival
Ventilation
Journal
Resuscitation
ISSN: 1873-1570
Titre abrégé: Resuscitation
Pays: Ireland
ID NLM: 0332173
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
23
02
2018
revised:
02
10
2018
accepted:
25
10
2018
pubmed:
8
1
2019
medline:
14
3
2020
entrez:
8
1
2019
Statut:
ppublish
Résumé
To evaluate in an established porcine post cardiac arrest model the effect of a mild hypercapnic ventilatory strategy on outcome. The left anterior descending coronary artery was occluded in 14 pigs and ventricular fibrillation induced and left untreated for 12 min. Cardiopulmonary resuscitation was performed for 5 min prior to defibrillation. After resuscitation, pigs were assigned to either normocapnic (end-tidal carbon dioxide (EtCO Twelve pigs were successfully resuscitated and eight survived up to 96 h, with animals in the hypercapnic group showing trend towards a longer survival. EtCO Mild hypercapnia after resuscitation was associated with better arterial pressure and lesser neuronal degeneration in this model. Nevertheless, no corresponding improvements in neurological recovery were observed.
Identifiants
pubmed: 30612967
pii: S0300-9572(18)31056-6
doi: 10.1016/j.resuscitation.2018.10.024
pii:
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110-117Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.