Seizures as an early symptom of autosomal dominant Alzheimer's disease.
Alzheimer's disease
Autosomal dominant
Dementia
Genetics
Positive predictive value
Seizures
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
20
06
2018
revised:
01
11
2018
accepted:
25
11
2018
pubmed:
8
1
2019
medline:
18
12
2019
entrez:
8
1
2019
Statut:
ppublish
Résumé
Our objective was to assess the reported history of seizures in cognitively asymptomatic mutation carriers for autosomal dominant Alzheimer's disease (ADAD) and the predictive value of seizures for mutation carrier status in cognitively asymptomatic first-degree relatives of ADAD patients. Seizure occurrence in the Dominantly Inherited Alzheimer Network observational study was correlated with mutation carrier status in cognitively asymptomatic subjects. Of 276 cognitively asymptomatic individuals, 11 (4%) had experienced seizures, and nine of these carried an ADAD mutation. Thus, in the Dominantly Inherited Alzheimer Network population, seizure frequency in mutation carriers was significantly higher than in noncarriers (p = 0.04), and the positive predictive value of seizures for the presence of a pathogenic mutation was 81.8%. Among cognitively asymptomatic ADAD family members, the occurrence of seizures increases the a priori risk of 50% mutation-positive status to about 80%. This finding suggests that ADAD mutations increase the risk of seizures.
Identifiants
pubmed: 30616208
pii: S0197-4580(18)30424-X
doi: 10.1016/j.neurobiolaging.2018.11.022
pmc: PMC6572755
mid: NIHMS1008072
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18-23Subventions
Organisme : Medical Research Council
ID : MR/L023784/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P50 AG005142
Pays : United States
Organisme : NIA NIH HHS
ID : UF1 AG032438
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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