GADD45A binds R-loops and recruits TET1 to CpG island promoters.
Animals
Cell Cycle
/ genetics
Cell Cycle Proteins
/ genetics
Cell Line
Chromatin
/ genetics
CpG Islands
/ genetics
DNA Methylation
/ genetics
DNA-Binding Proteins
/ genetics
Epigenesis, Genetic
/ genetics
Epigenomics
/ methods
HEK293 Cells
Humans
Mice
Mixed Function Oxygenases
/ genetics
Nuclear Proteins
/ genetics
Promoter Regions, Genetic
/ genetics
Protein Binding
/ genetics
Proto-Oncogene Proteins
/ genetics
RNA, Long Noncoding
/ genetics
Ribonuclease H
/ genetics
Transcription, Genetic
/ genetics
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
29
12
2017
accepted:
06
11
2018
pubmed:
9
1
2019
medline:
25
4
2019
entrez:
9
1
2019
Statut:
ppublish
Résumé
R-loops are DNA-RNA hybrids enriched at CpG islands (CGIs) that can regulate chromatin states
Identifiants
pubmed: 30617255
doi: 10.1038/s41588-018-0306-6
pii: 10.1038/s41588-018-0306-6
pmc: PMC6420098
mid: EMS80420
doi:
Substances chimiques
Cell Cycle Proteins
0
Chromatin
0
DNA-Binding Proteins
0
GADD45A protein, human
0
Nuclear Proteins
0
Proto-Oncogene Proteins
0
RNA, Long Noncoding
0
Mixed Function Oxygenases
EC 1.-
TET1 protein, human
EC 1.-
Ribonuclease H
EC 3.1.26.4
ribonuclease HI
EC 3.1.26.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
217-223Références
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