The role of HHV-6 and HHV-7 infections in the development of fibromyalgia.
Adult
Aged
Case-Control Studies
Female
Fibromyalgia
/ complications
Herpesvirus 6, Human
/ genetics
Herpesvirus 7, Human
/ genetics
Humans
Male
Middle Aged
Pain
/ complications
Pain Measurement
Roseolovirus Infections
/ complications
Severity of Illness Index
Viral Load
/ genetics
Viremia
/ complications
Fibromyalgia
HHV-6
HHV-7
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
06
09
2018
accepted:
13
11
2018
revised:
31
10
2018
pubmed:
9
1
2019
medline:
12
9
2020
entrez:
9
1
2019
Statut:
ppublish
Résumé
Human herpes virus-6 (HHV-6) and human herpes virus-7 (HHV-7) are immunomodulating viruses potentially affecting the nervous system. We evaluated the influence of HHV-6 and HHV-7 infections on fibromyalgia (FM) clinical course. Forty-three FM patients and 50 control group participants were enrolled. 39.50% (n = 17) FM patients had light A delta and C nerve fiber damage, 27.91% (n = 12) had severe A delta and C nerve fiber damage. 67.44% (n = 29) FM patients had loss of warm sensation in feet, loss of heat pain sensation, and increased cold pain sensation (34.90%, n = 15 in both findings). HHV-6 and HHV-7 genomic sequences in peripheral blood DNA in 23/43 (51.00%) and 34/43 (75.50%) of samples from FM patients and in 3/50 (6.00%) and 26/50 (52.00%) of samples from the control group individuals were detected. Active HHV-6 (plasma viremia) or HHV-7 infection was revealed only in FM patients (4/23, 17.40% and 4/34, 11.80%, respectively). A statistically significant moderate positive correlation was found between A delta and C nerve fiber damage severity and HHV-6 infection (p < 0.01, r = 0.410). 23/43 patients from the FM group and control group participants HHV-6 and 34/45 HHV-7 did have infection markers. A statistically significant moderate positive correlation was found between A delta and C nerve fiber damage severity and HHV-6 infection (p < 0.01, r = 0.410). No difference was found between detection frequency of persistent HHV-6 and HHV-7 infection between FM patients and the control group. Statistically significant correlation was observed between quantitation of changes in QST thermal modalities and HHV-6 infection. There was no correlation between A delta and C nerve fiber damage and HHV-7 infection.
Identifiants
pubmed: 30617851
doi: 10.1007/s13365-018-0703-8
pii: 10.1007/s13365-018-0703-8
pmc: PMC6505518
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
194-207Commentaires et corrections
Type : ErratumIn
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