Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm.
Bacterial Outer Membrane Proteins
/ genetics
Cell Membrane Permeability
Cytoplasm
/ metabolism
Drug Resistance, Multiple, Bacterial
Escherichia coli
/ metabolism
Escherichia coli Proteins
/ metabolism
Gene Knockout Techniques
Maltose
/ genetics
Maltose-Binding Proteins
/ metabolism
Membrane Transport Proteins
/ metabolism
Oligosaccharides
/ chemistry
Operon
/ genetics
Periplasm
/ metabolism
Periplasmic Binding Proteins
/ metabolism
Perylene
/ chemistry
Polysaccharides
/ metabolism
Porins
/ genetics
Receptors, Virus
/ genetics
Regulon
/ genetics
Trisaccharides
/ chemistry
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
13
11
2018
revised:
19
12
2018
accepted:
19
12
2018
entrez:
9
1
2019
pubmed:
9
1
2019
medline:
9
1
2019
Statut:
epublish
Résumé
Small molecule accumulation in Gram-negative bacteria is a key challenge to discover novel antibiotics, because of their two membranes and efflux pumps expelling toxic molecules. An approach to overcome this challenge is to hijack uptake pathways so that bacterial transporters shuttle the antibiotic to the cytoplasm. Here, we have characterized maltodextrin-fluorophore conjugates that can pass through both the outer and inner membranes mediated by components of the
Identifiants
pubmed: 30620010
doi: 10.26508/lsa.201800242
pii: LSA-2018-00242
pmc: PMC6311466
doi:
Substances chimiques
Bacterial Outer Membrane Proteins
0
Escherichia coli Proteins
0
MalE protein, E coli
0
Maltose-Binding Proteins
0
Membrane Transport Proteins
0
Oligosaccharides
0
Periplasmic Binding Proteins
0
Polysaccharides
0
Porins
0
Receptors, Virus
0
Trisaccharides
0
maltoporins
0
maltohexaose
34620-77-4
Perylene
5QD5427UN7
maltotriose
639K0T34IK
Maltose
69-79-4
maltodextrin
7CVR7L4A2D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e201800242Déclaration de conflit d'intérêts
The author (RA Stavenger) declares competing financial interests: RA Stavenger is an employee and shareholder of GlaxoSmithKline.
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