Small Multitarget Molecules Incorporating the Enone Moiety.
Alzheimer Disease
/ drug therapy
Antioxidants
/ chemical synthesis
Blood-Brain Barrier
/ drug effects
Chalcones
/ chemical synthesis
Cholinesterase Inhibitors
/ chemical synthesis
Circular Dichroism
Humans
Lipid Peroxidation
/ drug effects
Lipoxygenase Inhibitors
/ chemical synthesis
Molecular Docking Simulation
Protein Aggregation, Pathological
/ drug therapy
Structure-Activity Relationship
Alzheimer
acetylcholinesterase inhibitors
bis-chalcones
bis-ethers
chalcones
lipoxygenase inhibitors
multitarget
β-amyloid peptide
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
07 Jan 2019
07 Jan 2019
Historique:
received:
07
12
2018
revised:
24
12
2018
accepted:
28
12
2018
entrez:
10
1
2019
pubmed:
10
1
2019
medline:
16
3
2019
Statut:
epublish
Résumé
Chalcones represent a class of small drug/druglike molecules with different and multitarget biological activities. Small multi-target drugs have attracted considerable interest in the last decade due their advantages in the treatment of complex and multifactorial diseases, since "one drug-one target" therapies have failed in many cases to demonstrate clinical efficacy. In this context, we designed and synthesized potential new small multi-target agents with lipoxygenase (LOX), acetyl cholinesterase (AChE) and lipid peroxidation inhibitory activities, as well as antioxidant activity based on 2-/4- hydroxy-chalcones and the
Identifiants
pubmed: 30621100
pii: molecules24010199
doi: 10.3390/molecules24010199
pmc: PMC6337391
pii:
doi:
Substances chimiques
Antioxidants
0
Chalcones
0
Cholinesterase Inhibitors
0
Lipoxygenase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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