Activation and Proliferation of PD-1
Acute Kidney Injury
/ metabolism
Animals
Antigens, Surface
/ immunology
Cells, Cultured
Disease Models, Animal
Histocompatibility Antigens Class II
/ metabolism
Interleukin-2
/ immunology
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Knockout
Programmed Cell Death 1 Receptor
/ immunology
Random Allocation
Reference Values
Sensitivity and Specificity
T-Lymphocyte Subsets
/ immunology
T cells
immunology
ischemia-reperfusion
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
10
08
2018
accepted:
29
11
2018
pubmed:
10
1
2019
medline:
5
11
2019
entrez:
10
1
2019
Statut:
ppublish
Résumé
CD4 We used knockout mice, functional assays, and an established ischemic AKI model to investigate the role of various MHC class I and II molecules in regulating kidney DN T cells. We also studied human nephrectomy samples. Deficiency of DN T cells, a unique population of kidney T cells, depend on nonclassical
Sections du résumé
BACKGROUND
CD4
METHODS
We used knockout mice, functional assays, and an established ischemic AKI model to investigate the role of various MHC class I and II molecules in regulating kidney DN T cells. We also studied human nephrectomy samples.
RESULTS
Deficiency of
CONCLUSIONS
DN T cells, a unique population of kidney T cells, depend on nonclassical
Identifiants
pubmed: 30622155
pii: ASN.2018080815
doi: 10.1681/ASN.2018080815
pmc: PMC6362627
doi:
Substances chimiques
Antigens, Surface
0
Histocompatibility Antigens Class II
0
Interleukin-2
0
Programmed Cell Death 1 Receptor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
277-292Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK104662
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111209
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 by the American Society of Nephrology.
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