The anthelmintic drug praziquantel promotes human Tr1 differentiation.

Anthelmintics / pharmacology Antigens, CD / immunology Cell Differentiation / drug effects Cell Proliferation / drug effects Female Humans Immunologic Factors / pharmacology Interleukin-10 / immunology Male Praziquantel / pharmacology T-Lymphocytes, Regulatory / immunology
CD46 human CD4+ T cells immune regulation praziquantel regulatory T cells

Journal

Immunology and cell biology
ISSN: 1440-1711
Titre abrégé: Immunol Cell Biol
Pays: United States
ID NLM: 8706300

Informations de publication

Date de publication:
05 2019
Historique:
received: 26 09 2018
revised: 28 12 2018
accepted: 07 01 2019
pubmed: 10 1 2019
medline: 14 2 2020
entrez: 10 1 2019
Statut: ppublish

Résumé

Praziquantel (PZQ) is an anthelminthic human and veterinary drug used to treat trematode and cestode worms. Changes in immune responses have been demonstrated in humans following curative PZQ treatment of schistosome infections. These changes have been attributed to the removal of immunosupressive worms and immune responses to parasite antigens exposed from dying worms. To date, there has been no study investigating the potential direct effect of PZQ on the host immune cells. Herein, we analyzed the effect of PZQ on human CD4

Identifiants

DOI: 10.1111/imcb.12229 PMID: 30623486
pubmed: 30623486
doi: 10.1111/imcb.12229
doi:

Substances chimiques

Anthelmintics 0
Antigens, CD 0
IL10 protein, human 0
Immunologic Factors 0
Interleukin-10 130068-27-8
Praziquantel 6490C9U457

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

512-518

Informations de copyright

© 2019 Australasian Society for Immunology Inc.

Auteurs

Enwono Eyoh (E)

Institute of Immunology & Infection Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, King's Buildings, Edinburgh, UK.

Patrick McCallum (P)

Institute of Immunology & Infection Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, King's Buildings, Edinburgh, UK.

Justin Killick (J)

The MRC Centre for Inflammation Research, Edinburgh Centre for MS research, University of Edinburgh, Edinburgh, UK.

Seth Amanfo (S)

Institute of Immunology & Infection Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, King's Buildings, Edinburgh, UK.

Francisca Mutapi (F)

Institute of Immunology & Infection Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, King's Buildings, Edinburgh, UK.
NIHR Global Health Research Unit Tackling Infections to Benefit Africa (TIBA), Ashworth Laboratories, University of Edinburgh, King's Buildings, Edinburgh, UK.

Anne L Astier (AL)

The MRC Centre for Inflammation Research, Edinburgh Centre for MS research, University of Edinburgh, Edinburgh, UK.
Centre de Physiopathologie Toulouse-Purpan (CPTP) INSERM U1043, CNRS U5282, Université de Toulouse, Toulouse, France.
ORCID: 0000-0002-0144-3431

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Anthelminthiques › The anthelmintic drug praziquantel promotes...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › The anthelmintic drug praziquantel promotes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › The anthelmintic drug praziquantel promotes...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › The anthelmintic drug praziquantel promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The anthelmintic drug praziquantel promotes...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › The anthelmintic drug praziquantel promotes...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › The anthelmintic drug praziquantel promotes...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Praziquantel › The anthelmintic drug praziquantel promotes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › The anthelmintic drug praziquantel promotes...