OXTR methylation modulates exogenous oxytocin effects on human brain activity during social interaction.
cooperation
epigenetics
fMRI
intranasal
methylation
oxytocin
oxytocin receptor
precuneus
septum
social
Journal
Genes, brain, and behavior
ISSN: 1601-183X
Titre abrégé: Genes Brain Behav
Pays: England
ID NLM: 101129617
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
24
09
2018
revised:
07
01
2019
accepted:
07
01
2019
pubmed:
10
1
2019
medline:
3
2
2021
entrez:
10
1
2019
Statut:
ppublish
Résumé
Oxytocin (OT) effects on brain function and behavior are mediated by the oxytocin receptor (OXTR). The distribution of OXTR in the brain can profoundly influence social behavior. Emerging evidence suggests that DNA methylation of OXTR influences OXTR expression. Previously, we conducted a pharmaco-functional Magnetic Resonance Imaging (fMRI) study in which healthy subjects were randomized to 24 IU intranasal OT or placebo and imaged with fMRI while playing a dyadic social interaction task known as the iterated Prisoner's Dilemma (PD) game with same-sex partners. Here, we investigate whether DNA methylation of OXTR modulates the effect of intranasal OT on the neural response to positive and negative social interactions in the PD game. OXTR methylation did not modulate OT effects within brain regions where we previously reported OT effects in response to reciprocated (caudate nucleus) and unreciprocated cooperation (amygdala and anterior insula). However, OXTR methylation did modulate OT effects on the response to both reciprocated and unreciprocated cooperation in other brain regions such as the precuneus and visual cortex. Further restricting the analysis to OXTR rs53576 GG individuals revealed that OXTR methylation modulated OT effects on the precuneus response to reciprocated cooperation in men, the lateral septum response to reciprocated cooperation in women, and the visual cortex response to unreciprocated cooperation in men. These results suggest that OXTR methylation status may influence OT effects on mentalizing, attention and reward processing during social interactions. OXTR methylation may be important to consider if exogenous OT is used to treat social behavioral disorders in the future.
Substances chimiques
OXTR protein, human
0
Receptors, Oxytocin
0
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12555Subventions
Organisme : National Center for Advancing Translational Sciences of the National Institutes of Health
ID : UL1TR000454
Pays : International
Organisme : NIMH NIH HHS
ID : MH084068-01A1
Pays : United States
Organisme : NIH Blueprint for Neuroscience Research
ID : R21 TW009816
Pays : International
Informations de copyright
© 2019 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
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