Dopamine promotes colonic mucus secretion through dopamine D
distal colonic mucosa
dopamine
dopamine receptor
mucus
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
pubmed:
10
1
2019
medline:
7
1
2020
entrez:
10
1
2019
Statut:
ppublish
Résumé
Dopamine regulates gastrointestinal mucosal barrier. Mucus plays important roles in the protection of intestinal mucosa. Here, the regulatory effect of dopamine on rat colonic mucus secretion was investigated. RT-PCR, immunofluorescence, Periodic Acid-Schiff reagent assay, Alcian blue-Periodic Acid-Schiff staining, and enzyme-linked immunosorbent assay were used to observe the expression of dopamine receptor and the direct effect of dopamine on the colonic mucus. Mice injected intraperitoneally with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) destroying enteric dopamine (DA) neurons, rats microinjected with 6-hydroxydopamine (6-OHDA) into the bilateral substantia nigra damaging central dopaminergic neurons, and dopamine D
Identifiants
pubmed: 30624983
doi: 10.1152/ajpcell.00261.2017
doi:
Substances chimiques
Benzazepines
0
Mucin-2
0
SCH 23390
0
Receptors, Dopamine D5
137750-35-7
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM