Problems sleeping with prostate cancer: exploring possible risk factors for sleep disturbance in a population-based sample of survivors.
Adult
Aged
Aged, 80 and over
Cancer Survivors
/ psychology
Comorbidity
Cross-Sectional Studies
Depression
/ psychology
Health Status
Humans
Male
Middle Aged
Pain
/ epidemiology
Prevalence
Prostatic Neoplasms
/ physiopathology
Quality of Life
/ psychology
Risk Factors
Sleep Initiation and Maintenance Disorders
/ epidemiology
Adverse side effects
Anxiety
Depression
Insomnia
Pain
Prostate cancer
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
14
06
2018
accepted:
27
12
2018
pubmed:
11
1
2019
medline:
8
10
2019
entrez:
11
1
2019
Statut:
ppublish
Résumé
This study aimed to investigate the prevalence of sleeping problems in prostate cancer survivors and to explore the role of predisposing, precipitating and perpetuating factors in this process. Using a cross-sectional design, 3348 prostate cancer survivors between 2 and 18 years post diagnosis reported experiences of insomnia using the QLQC30, along with their sociodemographic characteristics, health status and treatment(s) received. The EQ5D-5L and QLQPR25 assessed survivors' overall and prostate cancer-specific health-related quality of life. A hierarchical multiple regression analysis was constructed with three blocks: (1) predisposing (e.g. demographics at diagnosis), (2) precipitating (e.g. disease extent, treatment) and (3) perpetuating factors (e.g. side effects). Nineteen percent of survivors reported significant problems sleeping. The final model accounted for 31% of the variance in insomnia scores (p < .001). In order of magnitude, associates of sleep disturbance were urinary symptoms (β = 0.22; p < .001), experiencing symptoms of depression/anxiety (β = 0.18; p < .001), hormone treatment-related symptoms (β = 0.12; p = .001), pain (β = 0.10; p < .001) and bowel symptoms (β = 0.06; p = .005). Having a lower education and more comorbidities at diagnosis also predicted sleep problems. Results suggest that it is the ongoing adverse effects of prostate cancer and its treatment (e.g. urinary symptoms) that put survivors most at risk of sleep problems. Strong associations with symptoms of depression/anxiety were also observed. Findings highlight the need for health care practitioners to treat and manage adverse effects of prostate cancer treatment in order to mitigate sleep disturbance in survivors.
Identifiants
pubmed: 30627919
doi: 10.1007/s00520-018-4633-z
pii: 10.1007/s00520-018-4633-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3365-3373Subventions
Organisme : Prostate Cancer UK
ID : NI09-03
Pays : United Kingdom
Organisme : National Cancer Control Programme RoI
ID : NA
Organisme : Public Health Agency NI
ID : NA
Organisme : Prostate Cancer UK
ID : NI-PG13-001
Pays : United Kingdom
Organisme : Prostate Cancer UK
ID : NI09-03 & NI-PG13-001
Pays : United Kingdom
Organisme : Health Research Board
ID : HRA_HSR/2010/17
Pays : Ireland
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