Emergence of Madariaga virus as a cause of acute febrile illness in children, Haiti, 2015-2016.
Animals
Antibodies, Viral
/ blood
Child
Child, Preschool
Communicable Diseases, Imported
/ epidemiology
Culex
/ virology
Disease Outbreaks
Encephalitis Virus, Eastern Equine
/ classification
Encephalomyelitis, Eastern Equine
/ epidemiology
Female
Haiti
/ epidemiology
Humans
Male
Phylogeny
RNA, Viral
/ blood
Schools
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
07
08
2018
accepted:
03
11
2018
entrez:
11
1
2019
pubmed:
11
1
2019
medline:
15
2
2019
Statut:
epublish
Résumé
Madariaga virus (MADV), also known as South American eastern equine encephalitis virus, has been identified in animals and humans in South and Central America, but not previously in Hispaniola or the northern Caribbean. MADV was isolated from virus cultures of plasma from an 8-year-old child in a school cohort in the Gressier/Leogane region of Haiti, who was seen in April, 2015, with acute febrile illness (AFI). The virus was subsequently cultured from an additional seven AFI case patients from this same cohort in February, April, and May 2016. Symptoms most closely resembled those seen with confirmed dengue virus infection. Sequence data were available for four isolates: all were within the same clade, with phylogenetic and molecular clock data suggesting recent introduction of the virus into Haiti from Panama sometime in the period from October 2012-January 2015. Our data document the movement of MADV into Haiti, and raise questions about the potential for further spread in the Caribbean or North America.
Identifiants
pubmed: 30629592
doi: 10.1371/journal.pntd.0006972
pii: PNTD-D-18-01210
pmc: PMC6328082
doi:
Substances chimiques
Antibodies, Viral
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0006972Subventions
Organisme : NIAID NIH HHS
ID : R01 AI126357
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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