Apolipoprotein D overexpression alters hepatic prostaglandin and omega fatty acid metabolism during the development of a non-inflammatory hepatic steatosis.
Animals
Apolipoproteins D
/ genetics
Disease Models, Animal
Fatty Acids, Omega-3
/ metabolism
Fatty Acids, Omega-6
/ metabolism
Fatty Acids, Unsaturated
/ metabolism
Fatty Liver
/ genetics
Liver
/ metabolism
Male
Mice
Mice, Transgenic
PPAR gamma
/ metabolism
Prostaglandin D2
/ analogs & derivatives
Prostaglandins
/ metabolism
Apolipoprotein D
Hepatic steatosis
Omega-3 fatty acid
Omega-6 fatty acid
Peroxisome proliferator-activated receptor γ
Prostaglandin 15d-PGJ(2)
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
19
07
2018
revised:
17
12
2018
accepted:
06
01
2019
pubmed:
11
1
2019
medline:
23
10
2019
entrez:
11
1
2019
Statut:
ppublish
Résumé
Apolipoprotein D (ApoD) is a secreted lipocalin associated with neuroprotection and lipid metabolism. Overexpression of ApoD in mouse neural tissue induces the development of a non-inflammatory hepatic steatosis in 12-month-old transgenic animals. Previous data indicates that accumulation of arachidonic acid, ApoD's preferential ligand, and overactivation of PPARγ are likely the driving forces in the development of the pathology. However, the lack of inflammation under those conditions is surprising. Hence, we further investigated the apparent repression of inflammation during hepatic steatosis development in aging transgenic animals. The earliest modulation of lipid metabolism and inflammation occurred at 6 months with a transient overexpression of L-PGDS and concomitant overproduction of 15d-PGJ
Identifiants
pubmed: 30630053
pii: S1388-1981(18)30165-3
doi: 10.1016/j.bbalip.2019.01.001
pii:
doi:
Substances chimiques
15-deoxyprostaglandin J2
0
APOD protein, human
0
Apolipoproteins D
0
Fatty Acids, Omega-3
0
Fatty Acids, Omega-6
0
Fatty Acids, Unsaturated
0
PPAR gamma
0
Prostaglandins
0
Prostaglandin D2
RXY07S6CZ2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
522-531Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.